Transient lupus erythematosus-like
Introduction
Introduction The main clinical feature of systemic lupus erythematosus is edematous erythema on both sides of the cheek. The erythema on the bridge of the nose is often connected to the buccal erythema on both sides to form a butterfly-like rash.
Cause
Cause
The cause of transient lupus erythematosus:
The cause is unknown, and it is currently considered to be related to genetic, viral or bacterial infections, physical factors, endocrine factors, and mental factors. Certain drugs (such as hydrazide drugs, anti-epileptic drugs, procainamide, etc.), sunlight and ultraviolet rays, pregnancy and childbirth can be induced. There are many autoantibodies in the serum of this disease, but the most important one is lupus erythematosus cells (LE cells).
Examine
an examination
Related inspection
Anti-cardiolipin antibody interleukin 5 (iL-5) lupus erythematosus cells (LEC) lupus cell test anti-mitochondrial antibody
A diagnosis of transient lupus erythematosus:
Common symptoms include:
1, systemic symptoms: fever, fatigue, weight loss and so on.
2, facial erythema and various rashes, skin allergies after sun exposure.
3, hair loss.
4, repeated ulcers in the mouth.
5, joint pain, muscle pain, muscle weakness, cold in the limbs from white to purple and then red.
6, chest tightness, shortness of breath, dry cough.
7, mental disorders, seizures, hemiplegia and so on.
8, loss of appetite, vomiting, abdominal distension and so on.
9, nasal discharge, bleeding gums, skin purpura and so on.
10. Lymph nodes are swollen.
Basic clinical examinations include:
1, blood routine: may have anemia, white blood cell reduction, thrombocytopenia.
2, urine routine: hematuria, proteinuria and so on.
3, autoantibodies: ANA, anti-dsDNA, anti-Sm, anti-RNP, anti-SSA / SSB, anti-rRNP, AHA, mDNA, ACL, RF, anti-Hu, PCNA and other antibodies can be positive.
4, decreased complement, elevated immunoglobulin.
5, lupus belt test positive.
6, renal biopsy: the diagnosis, treatment and estimation of prognosis of lupus, significant.
7, X-ray, CT and B-ultrasound.
Diagnosis
Differential diagnosis
Transient lupus erythematosus-like symptoms:
Transient lupus erythematosus should be differentiated from symptoms manifested by other diseases: should be associated with other connective tissue diseases, bacterial or viral infectious diseases, histiocytosis X, malignant reticuloendotheliosis, thrombocytopenia, Hemolytic anemia, various types of kidney disease, hepatitis, myocardial-pericarditis, differentiation of nervous system diseases. Especially need to identify with lupus syndrome and neonatal lupus syndrome.
(1) Lupus-like syndrome: The most common one is systemic lupus erythematosus caused by drugs. This syndrome can be seen in some symptoms and signs similar to SLE, and laboratory results, sometimes difficult to distinguish. The following conditions are helpful in identifying: taking medication history, gender differences are not obvious, clinical symptoms are mild, visceral involvement, kidney disease, butterfly erythema, mouth ulcers, hair loss, and white blood cells, thrombocytopenia, and hypocomplementemia are rare. Anti-Sm antibody and anti-n-DNA (FARR) antibody were negative. The most important feature is that the clinical symptoms and laboratory signs disappear after stopping the drug, and then reappear when the drug is used. Sometimes antinuclear antibodies exist for a longer period of time and generally have a good prognosis.
(B) neonatal lupus erythematosus syndrome: the disease is seen in infants under 6 months. Most of the mothers of the children suffer from SLE or other connective tissue diseases, and there are RO antigen (Sjogren's syndrome A antigen) and La antigen (Sjogren's syndrome B antigen) in the serum. Children with symptoms after birth, mainly for congenital conduction block, lupus-like dermatitis, auto-hemolytic anemia, RO and La antigen positive in vivo. In addition, often accompanied by congenital heart disease, various defects and endocardial fibroelastosis, white blood cells and thrombocytopenia. The typical manifestations of lesions are scaly and ring-shaped erythema, which are found in the exposed parts, ie at the top of the head, neck and eyelids, and appear to be discoid erythema. The disease is a self-limiting disease, the blood abnormalities are improved within 6 weeks, and the skin lesions can disappear within 6 months. In addition to children with heart disease, the general prognosis is good. It is not known why puberty can become a SLE.
Common symptoms include:
1, systemic symptoms: fever, fatigue, weight loss and so on.
2, facial erythema and various rashes, skin allergies after sun exposure.
3, hair loss.
4, repeated ulcers in the mouth.
5, joint pain, muscle pain, muscle weakness, cold in the limbs from white to purple and then red.
6, chest tightness, shortness of breath, dry cough.
7, mental disorders, seizures, hemiplegia and so on.
8, loss of appetite, vomiting, abdominal distension and so on.
9, nasal discharge, bleeding gums, skin purpura and so on.
10. Lymph nodes are swollen.
Basic clinical examinations include:
1, blood routine: may have anemia, white blood cell reduction, thrombocytopenia.
2, urine routine: hematuria, proteinuria and so on.
3, autoantibodies: ANA, anti-dsDNA, anti-Sm, anti-RNP, anti-SSA / SSB, anti-rRNP, AHA, mDNA, ACL, RF, anti-Hu, PCNA and other antibodies can be positive.
4, decreased complement, elevated immunoglobulin.
5, lupus belt test positive.
6, renal biopsy: the diagnosis, treatment and estimation of prognosis of lupus, significant.
7, X-ray, CT and B-ultrasound.
