Serum immunoglobulin can be elevated
Introduction
Introduction Immunoglobulin refers to an animal protein having antibody activity. It is mainly found in plasma and is also found in other body fluids, tissues and some secretions. Serum immunoglobulins (Ig) include: IgG, IgA, IgM, IgD, IgE. The normal range is IgG 7.6 to 16.6 g/L; IgA 0.71 to 3.35 g/L; IgM 0.48 to 2.12 g/L; IgD 0.01 to 0.04 g/L; IgE 0.001 to 0.009 g/L.
Cause
Cause
The cause of elevated serum immunoglobulin
1. Chronic liver disease: including autoimmune chronic hepatitis, chronic active hepatitis, cirrhosis, chronic alcoholic liver disease, primary biliary cirrhosis, etc.; the degree of globulin increase is related to the severity of liver disease.
2. Autoimmune diseases.
3. Chronic inflammation and chronic infections: such as tuberculosis, malaria, etc.
4. M globulinemia: such as multiple myeloma, lymphoma, primary macroglobulinemia.
Examine
an examination
Related inspection
Mixed lymphocyte culture test cyclic guanosine monophosphate serum viscosity (SV)
Serum immunoglobulin can be elevated
On the basis of chronic active hepatitis and cirrhosis, a large area of necrosis of liver tissue can occur due to various factors, which is called "chronic severe hepatitis" in clinical practice. The main clinical manifestations are:
1 The patient has a history of chronic active hepatitis, or even if there is no history of symptoms and signs of chronic hepatitis, but there is hepatitis virus serology: the basis for diagnosis.
2 Highly fatigued and severe gastrointestinal symptoms.
3 serum bilirubin rose rapidly, greater than 171 micromoles / 100 ml.
4 There are signs of chronic liver disease such as dull complexion, liver palm, spider mites and hepatosplenomegaly.
5 Ascites appeared early, often more.
6 albumin / globulin (A / G) inverted or Y-globulin increased.
7 Enzymatic separation of the enzyme is obvious.
8 occurred in liver coma late, died of gastrointestinal bleeding and renal failure.
9 The disease progressed relatively slowly, and the prothrombin activity (PTA) showed a progressive decline.
Diagnosis
Differential diagnosis
Serum immunoglobulin can increase confusing symptoms
Both chronic liver disease and malaria cause an increase in serum immunoglobulin.
Chronic liver disease: the performance is as follows:
1. Bleeding. It is characterized by black stools. When it is severe, it is dark and shiny. It is like tar on paved roads. When it is severe, it can also solve blood.
2. Spiritual change. The mind is awkward, sleepy or unusually excited, restless, and insane. Even ordinary arithmetic can't be done. In severe cases, you can be unconscious. These symptoms are caused by harmful substances produced by liver disease that stimulate the brain. It is clinically called hepatic encephalopathy. The degree can be light or heavy, and the duration can be long or short.
3. Huang Wei. Yellow sputum (skin, white eyeballs appear yellow), or the original jaundice is aggravated. The urine is like a tea.
4. Fever. There is a high fever of unknown cause. This indicates a serious infection in the body. Liver cancer can manifest as long-term fever, and fever will undoubtedly increase the burden on the liver.
5. Abdominal pain. Right upper quadrant pain or total abdominal pain, more painful when pressed by hand.
6. Abdominal block. The longer the abdomen mass, the more often it can be touched.
7. Bloating. Abdominal swelling is increased and abdominal circumference is increased. It shows that ascites is produced, usually called "water sputum", which is one of the manifestations of liver dysfunction.
8. Lack of urine. Drinking water is normal, but the total urine volume in 24 hours is less than 400 ml.
Malaria: Malaria infectious diseases caused by malaria parasites infected by Anopheles mosquitoes. The clinical features are characterized by periodic chills, fever, headache, sweating and anemia, and splenomegaly. The incidence of children is high, and most of them are popular in summer and autumn. Plasmodium is parasitic on infectious diseases caused by the human body. Infected by the bite of a malaria mosquito or the blood of a person with a Plasmodium. Different malaria parasites cause vivax malaria, three-day malaria, falciparum malaria and oval malaria. The main manifestations of this disease are periodic regular attacks, body chills, fever, and sweating. After long-term multiple attacks, it can cause anemia and splenomegaly. Malaria is a parasitic disease caused by Plasmodium, which is more common in summer and autumn. It can occur in tropical and subtropical regions all year round and is prone to prevalence.
