Increased serum calcitonin level
Introduction
Introduction Serum calcitonin is a hormone secreted by thyroid follicular cells. When it is elevated for some reason, it can increase the calcium excretion of the kidney and lower the blood calcium concentration. Endemic goiter is a type of goiter. There was no obvious clinical symptoms in the early stage, and the thyroid was mild, moderately diffuse, soft, and no tenderness. Very few people with obvious swelling may experience symptoms of compression such as difficulty breathing, difficulty swallowing, hoarseness, and irritating cough. Posterior sternal goiter may have symptoms of esophageal or superior vena cava compression.
Cause
Cause
The cause of elevated serum calcitonin levels
When the medullary thyroid carcinoid changes, the patient's serum calcitonin concentration increases, and the blood calcium concentration decreases. Pregnant women and children have elevated serum calcitonin levels due to bone growth, and serum calcitonin levels decrease after menopause. Serum calcitonin levels can be significantly increased in patients with renal insufficiency and lung cancer, and can also be used as an activity indicator for malignant tumors such as lung cancer.
Examine
an examination
Related inspection
Blood test blood routine
Examination of elevated serum calcitonin levels
Blood test: Calcitonin is a thirty-two peptide containing a disulfide bond with a molecular weight of 3,400. Normal human serum has a calcitonin concentration of 10-20 ng/L and a plasma half-life of less than 1 h, which is mainly degraded and excreted in the kidney. The main role of calcitonin is to lower blood calcium and blood phosphorus. The main target organ is bone, which also has a certain effect on the kidney.
Diagnosis
Differential diagnosis
Symptoms of elevated serum calcitonin levels
Low serum testosterone levels: What is the impact of hypogonadism and decreased testosterone levels on men's health has been a controversial issue. Although studies have shown that high doses of testosterone or other exogenous androgens may be harmful to health, a low serum testosterone concentration may indicate an increase in mortality in older men. Testosterone levels may be a risk factor for coronary atherosclerosis. Testosterone, also known as testosterone, testosterone or testosterone, is a steroid hormone secreted by the male testis or female ovaries, and the adrenal glands secrete a small amount of testosterone. It is the main male sex hormone and anabolic hormone. The amount of testosterone secreted by adult males is 20 times that of adult females. In the follicular phase of the normal female menstrual cycle, the serum testosterone concentration averaged 0.43 ng/ml and the upper limit was 0.68 ng/ml.
Serum testosterone concentration is significantly increased: the normal menstrual cycle follicular phase, the average serum testosterone concentration is 0.43ng / ml, the high limit is 0.68ng / ml, such as more than 0.7ng / m1 (equal to 2.44nmol / L), known as high Testosteroneemia, or hyperandrogenism. Ovarian, adrenal cortex, etc. can synthesize cholesterol from acetic acid, or absorb cholesterol from the blood as a matrix, synthesize steroid hormones, and secrete into the blood circulation. The androgens in the blood circulation are mainly DHEAS, DHEA, androstenedione (4A), testosterone (T) and dihydrotestosterone (DHT). High testosteroneemia, which is formed by the high levels of these hormones, especially testosterone in the blood.
Serum alkaline phosphatase can be progressively increased: liver metastasis or liver disease of cancer, serum alkaline phosphatase can be progressively increased, often more than 20 gold units, -glutamyl transpeptidase (-GT) May be positive. Alanine aminotransferase and other liver function changes were not obvious. Most patients die in the short term. It is characterized by loss of appetite, nausea and weight loss in the liver area. Sometimes jaundice can occur. The main feature of the diagnosis is that the liver is progressively enlarged in a short period of time, the normal contour disappears, and the inflexibility is inconsistent with nodules. When the metastases are larger than 2cm, the health search can be detected by ultrasound and CT.
Reduced serum HDL-C levels: Hyperlipidemia is a systemic disease in which blood cholesterol (TC) and/or triglyceride (TG) is too high or high-density lipoprotein cholesterol (HDL-C) is too low. Modern medicine calls it dyslipidemia.
