Ig and complement deposition in and around the vessel wall
Introduction
Introduction Ig and complement deposition on the wall of the blood vessel are one of the symptoms of urticaria vasculitis. The cause is unknown, and there are reports of hypersensitivity vasculitis caused by iodine allergy, repeated cold stimulation, and allergens such as viruses, bacteria, and parasites. The clinical manifestations are mainly that the skin wheal lasts for more than 24 hours; with fever, joint pain, abdominal pain, etc.; swollen lymph nodes; severe cases may have kidney damage.
Cause
Cause
The cause of Ig and complement deposition in the wall of blood vessels
The cause is unknown, and there are reports of hypersensitivity vasculitis caused by iodine allergy, repeated cold stimulation, and allergens such as viruses, bacteria, and parasites.
Examine
an examination
Related inspection
Angiotensin converting enzyme
Examination and diagnosis of Ig and complement deposition in the vessel wall and surrounding
The clinical manifestations are mainly that the skin wheal lasts for more than 24 hours; with fever, joint pain, abdominal pain, etc.; swollen lymph nodes; severe cases may have kidney damage.
Laboratory indicators: dermal endothelial cells are swollen, there are more neutrophils around the blood vessels, nuclear dust and red blood cells spilling out, and fibrin-like degeneration in the blood vessel wall. Rapid, severe and long-lasting hypocomplementemia; histopathological examination revealed leukocyte fragmentation vasculitis. Direct fluoroscopy revealed Ig and complement deposition in and around the vessel wall.
Diagnosis
Differential diagnosis
Symptoms of Ig and complement deposition in the wall of the blood vessel
1. Chronic urticaria sometimes shows vascular endothelial cell swelling in histology; in addition to monocytes, there are also neutrophil infiltration, and nuclear dust is also visible. Most of the inflammatory cells infiltrate the vascular wall, but no fibrosis. Characteristics of necrotic vasculitis such as necrosis.
2, the disease also needs to be differentiated from systemic lupus erythematosus (SLE), the former in addition to pathological examination, can also be distinguished by a simple "slide film rash": using a slide on the UV lesion, the original Some erythema subsided, and the clinically inconspicuous purpura became visible to the naked eye; according to UV patients anti-ds2DNA antibody and anti-Sm antibody negative, no or only slight visceral damage, can be identified with SLE.
