androgen excess
Introduction
Introduction The male hormone in the body has a fixed amount. If it exceeds this amount, it is called female androgen high. Female androgen high is easy to cause women to not ovulate, less menstruation or even amenorrhea, thus making women infertile.
Cause
Cause
Causes of excessive androgen
1, due to excessive secretion of ovary or adrenal cortex.
2, may also be caused by abnormal peripheral transformation.
3, is the enzyme system disorder in the process of steroid hormone biosynthesis, such as aromatase deficiency, androstenedione can not be converted to estrone, testosterone can not be converted to estradiol, androstenedione, especially testosterone Overfilled.
4, 60% of testosterone in the blood combined with beta globulin, called testosterone-estradiol-binding globulin (TEBG), about 38% (mainly androstenedione) combined with albumin, free testosterone only accounted for 2 %, but it is active. If TEBG binds to estradiol and the testosterone decreases, the free testosterone in the blood increases.
5, hyperinsulinemia caused by insulin resistance can stimulate the ovary to secrete a large amount of androgen, a small number of high androgen women due to special reasons, such as adrenal and ovarian tumors, adrenal hyperplasia, Cushing syndrome, high prolactinemia Caused by a disease or drug.
Examine
an examination
Related inspection
Sex hormone binding protein urine routine
The main symptoms of excessive androgen: excessive body hair, thick, even long beard, menstrual disorders and infertility.
Conduct six tests of sex hormones: it is a routine basic examination of the reproductive department. That is, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), testosterone (T), prolactin (PRL), basically meet the clinician's screening for endocrine disorders or not Check and general understanding of physiological functions.
Diagnosis
Differential diagnosis
Symptoms of excessive androgen confusing:
Androgen dependence: Androgen dependence is more common in androgen-dependent prostate cancer. Androgen is produced by the testes. In addition, the adrenal cortex and ovaries can secrete a small amount of androgens. After the male child enters puberty, the testicle begins to secrete androgen to promote the development of the reproductive organs, secondary sexual characteristics and sexual home and sexual desire. Androgens also stimulate appetite, promote protein synthesis, and reduce urinary nitrogen excretion.
Androgen is too small: androgen (xiongxingjisu) is also known as "male hormone." A hormone that promotes maturity and secondary sexual characteristics in males and maintains normal sexual desire and reproductive function. The testosterone (testosterone) secreted by the testes is mainly used. In addition, the adrenal cortex and ovaries can secrete a small amount of androgen. Is a steroid hormone. If the secretion of androgen is too small, it will not only affect the growth and development of the human body, but also have low sexual function, and there will be female characteristics without male male wind.
