Sophisticated appearance
Introduction
Introduction The "skilled" appearance is one of the clinical manifestations of full-term small samples. All newborns born from 28 weeks to 37 weeks of gestation are premature infants, fetuses are 38-42 weeks, and those weighing <2500g are full-term small samples.
Cause
Cause
Intrauterine infection affects the growth and development of the fetus; placental insufficiency; pregnant women are sick during pregnancy; fetuses such as certain chromosomal diseases or the like.
Most of them are related to various factors leading to placental dysfunction, pregnancy-induced hypertension syndrome, chronic hypertension, pregnancy infection (such as rubella, giant cell inclusion disease, toxoplasmosis), chronic heart disease, cyanotic cardiovascular abnormalities, Early marriage, primiparity, twins, high maternal maternal, tobacco and alcohol addiction, severe malnutrition, vitamin A deficiency, lack of folic acid during pregnancy, high altitude areas, application of adrenocortical hormone or other immunosuppressive drugs, long-term use of tetracycline or antibiotics at the end of pregnancy Metabolic drugs, abnormal umbilical cord attachment sites, single umbilical arteries, congenital malformations, chromosomal abnormalities and other factors can cause fetal malnutrition, congenital malformations and hypoxia.
Examine
an examination
Related inspection
Thyroglobulin blood routine
Most of the clinical manifestations were skilled appearance, good response, weight loss and varying degrees of malnutrition, accounting for about 59%. Respiratory distress and hypoxia, hard swelling is almost no, the skull is softened and deformed less, no hepatosplenomegaly found, the nerve reflex is mostly good, the deformity accounted for 6. 5 %,
The full-term small sample is characterized by thin skin, dry and peeling, less fetal hair, more fetal fat, fine hair, less cartilage development, formed ear canal, soft fingers and toenails. The breast can have nodules. There are lines on the soles of the feet. The scrotum is more wrinkled, but the testicles of the baby boy have dropped, and the labia majora can cover the labia minora. Physiological jaundice is not obvious. Physiological weight loss is not obvious. The heat-producing reaction is better, the sweating is better, the activity is more lively, the crying is louder, and the sucking power is stronger.
Diagnosis
Differential diagnosis
Gradually becoming thicker refers to the patient's rough and faint changes in the appearance of the patient during the development process due to bone lesions. Gradually becoming bulky is one of the typical manifestations of mucopolysaccharidosis type I. It is a group of hereditary mucopolysaccharide metabolic disorders caused by lysosome abnormalities. The common clinical features of congenital rheumatism caused by the deficiency of enzyme activity and the incomplete decomposition of glucosamine are the varying degrees of osteophyte changes. , mental retardation, visceral involvement and corneal opacity; biochemical characteristics are acid mucopolysaccharide catabolism defects such that the accumulation of excessive mucopolysaccharide in the cells and excessive mucopolysaccharide in the urine. When the child is born, his appearance is still normal, but he can quickly show that the movement and mental development are backward to 1 to 2 years old, which can clearly reveal the characteristics of the disease. The child's appearance gradually became rough, the nose was wide and flat, the eye distance was wide, the lip was thick, the tongue was large, and the ear was low and the teeth were small and sparse. The skin has thicker hair and longer eyebrows. The head circumference increases the sagittal suture and the anterior and posterior diameter increases (scapular head), occasionally the hydrocephalus of the hydrocephalus is severely deformed, the fingers are short and short, and the spine is bent backward. The joints gradually contracted and straightened, and the fingers were fixed in the semi-flexion position, and the claws were short.
Appearance: Hutchinson-Gilford Syndrome, also known as childhood premature aging, is a genetic disease, first reported by Hutchinson in 1886. The process of physical aging in patients with premature aging is 5 to 10 times faster than normal. The appearance of the patient is like the elderly, and the organ is also rapidly declining, causing the physiological function to decline. Symptoms include small size, hair loss and longer teeth. Children who suffer from this rare disease, even if they are only 16 years old, look like six or seventy-year-olds. Sick children generally only live to 7 to 20 years old, most of them will die of aging diseases, such as cardiovascular disease, there is no effective treatment at present, only drugs for treatment. Although the disease is a congenital hereditary disease, it is not certain whether it is autosomal recessive or dominant inheritance. The disease is a syndrome characterized by delayed development and progressive senile degenerative changes in infancy. The process of aging of patients is 5 to 10 times faster than normal. The appearance of the patient is like the elderly, and the organs are also rapidly declining, causing the physiological function to decline. Symptoms include small size, hair loss and longer teeth. Based on these, it can be used as a basis for diagnosis.
