stop early
Introduction
Introduction Stopping early refers to the early closure of women due to various diseases and other factors, and the age of menopause is earlier than that of normal women. Stopping is one of the clinical manifestations of premature ovarian failure. Normal women's ovarian function begins to decline when they are 45 to 50 years old. If there is a sign of decline before the age of 40, it is called premature ovarian failure. There are many reasons for premature aging, including immune factors, cytogenetic factors, and physical and chemical factors such as surgery and infection. Premature ovarian function affects women's quality of life. At present, the clinical supplementation of exogenous estrogen and progesterone is mainly used to compensate for the deficiency of ovarian function and delay the pathological process.
Cause
Cause
The reasons for premature menopause mainly include six aspects, irregular life, smoking, drinking; various pituitary tumors, uterus or ovarian tumors; external mechanical causes including repeated abortion, intrauterine adhesions, multiple curettage Factors such as damage to the lining of the endometrium; long-term use of contraceptives, overdose of hemostatic drugs, etc.; treatment of mental and neurological diseases for too long; high mental stimulation; endocrine causes, the effects of some endocrine glands in the body, Such as adrenal gland, thyroid, pancreas and other dysfunction, work pressure and insomnia rest is not good. In addition, it is also related to genetic factors.
Examine
an examination
Related inspection
Gynecological ultrasound examination gynecological examination
Clinically, according to amenorrhea, blood FSH, LH significantly increased, blood E2 extreme bottom and ovarian tissue biopsy without primordial follicles can be diagnosed.
If an ovarian biopsy is found to have follicles, it may be that the ovary lacks FSH (follicle stimulating hormone) receptor and is responsive to gonadotropin, a condition known as ovarian insensitivity syndrome.
Ovarian biopsy is generally not recommended because ovarian insensitivity syndrome is less common and there is less chance of pregnancy. If available, ovarian tissue antibodies and anti-adrenal antibodies can be detected to detect related autoimmune diseases.
Decreased ovarian function can cause different degrees of hot flashes, sweating, anxiety and depression, upset and irritability and other menopausal syndromes; due to vaginal dryness, lubrication of the feet, not only will the couple's sexual life be greatly affected, but also cause vaginal mucosal damage, It is easy to cause viral and bacterial infections, induce vaginitis or aggravate the original condition, and bring great impact on quality of life and mental health.
Diagnosis
Differential diagnosis
Ovarian amenorrhea: If the ovary is absent or dysplastic, ovarian damage or premature aging, so that the body does not produce sex hormones, the endometrium can not grow, nor can it periodically change and exfoliate, menstruation can not come, this amenorrhea, called Ovarian amenorrhea. According to the medical history, physical examination, gynecological examination, etc. can be diagnosed.
Clinically, according to amenorrhea, blood FSH, LH significantly increased, blood E2 extreme bottom and ovarian tissue biopsy without primordial follicles can be diagnosed.
If an ovarian biopsy is found to have follicles, it may be that the ovary lacks FSH (follicle stimulating hormone) receptor and is responsive to gonadotropin, a condition known as ovarian insensitivity syndrome.
Ovarian biopsy is generally not recommended because ovarian insensitivity syndrome is less common and there is less chance of pregnancy. If available, ovarian tissue antibodies and anti-adrenal antibodies can be detected to detect related autoimmune diseases.
Decreased ovarian function can cause different degrees of hot flashes, sweating, anxiety and depression, upset and irritability and other menopausal syndromes; due to vaginal dryness, lubrication of the feet, not only will the couple's sexual life be greatly affected, but also cause vaginal mucosal damage, It is easy to cause viral and bacterial infections, induce vaginitis or aggravate the original condition, and bring great impact on quality of life and mental health.
