Gottron's sign of dermatomyositis

Introduction

Introduction Dermatomyositis Gottron sign: About 70% of dermatomyositis appears. It is characterized by red-purple maculopapular rash on the metacarpophalangeal joint and proximal knuckle joint. The top surface is flat, with a little desquamation. After a long time, the skin shrinks and the pigmentation subsides. In the nail folds, visible telangiectasia and sputum can help to diagnose. This sign was first described by Gottron in 1930 and is considered to be a specific rash of DM. The finger joints, the flat purple-red papules on the extension of the metacarpophalangeal joints, with scaly scales on the surface, are clearly defined. In 30% of patients, there is atrophy, hypopigmentation and telangiectasia after the lesions have subsided.

Cause

Cause

It occurs in dermatomyositis and is one of the characteristic skin lesions of skin manifestations.

The cause of dermatomyositis is unknown;

The following related factors have been found: genetic susceptibility factors; nuclear antigen (ANA) and cytoplasmic antigen autoantibodies; infectious pathogens; drug-derived; silicone breast augmentation.

Examine

an examination

Related inspection

Electromyography anti-ENA antibody anti-polymyositis-1 antibody extractable nuclear antigen (ENA) autoantibody band analysis

The rash occurs in the metacarpophalangeal joint, the knuckle joint, and the metatarsophalangeal joint. The internal iliac joint can also be seen. The rash is a purple-red papule, which can be fused into plaques with fine scales on the surface. The central depression is atrophy and hypopigmentation. There is telangiectasia.

Diagnosis

Differential diagnosis

Dermatomyositis (DM), also known as dermatitis dermatomyositis (poikilodermatomyositis) is an autoimmune connective tissue disease, mainly involving the striated muscle, a non-suppurative inflammatory lesion with lymphocytic infiltration, which may be accompanied by or Without a variety of skin damage, it can also be associated with various visceral damage.

Polymyositis (PM) refers to the disease of this group without skin damage. The exact cause is not clear enough. It may be a virus infection. The abnormal immune recognition of the body and vascular lesions may also be related to each other. For example, lentivirus infection of striated muscle fibers can lead to changes in the antigenicity of muscle fibers, which are mistaken by the immune system as "existing" to cause vasculitis.

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