skin heterochromia
Introduction
Introduction One of the characteristic skin lesions of dermatomyositis, pigmentation at the same site, punctate pigmentation, punctate keratinization, telangiectasia, etc., consciously itching, more common in the face, neck, trunk.
Cause
Cause
Vascular atrophic cutaneous heterochromia
Cause: This disease is a vascular atrophic disease, it may be a sign, not an independent disease.
2. Congenital cutaneous heterochromia with bullae
May be autosomal recessive, traumatic or spontaneous bullae, with extremities and joints, often with hemorrhagic gingivitis, abnormal tooth development, malnutrition, esophageal and urethral stricture.
Examine
an examination
Related inspection
Fungal histopathology
General pathological changes:
1. The epidermis is atrophied, and the melanin of the heterochromatic skin is significantly increased.
2. A small amount of gelatinous bodies can be seen.
3. Basal cell vacuolar degeneration, severe epidermal separation, epidermis or subepidermal blister formation.
4. The dermal papillary vasodilation showed phagocytes, no obvious lymphocytic infiltration.
Clinical features:
1. In the neonatal period or early childhood, there is no significant gender difference.
2. May be autosomal recessive.
3. Traumatic or spontaneous bullae, especially at the extremities and joints.
4. Skin color with progressive atrophy.
5. Light sensitive.
6. The palmar keratosis is excessive.
7. Often accompanied by hemorrhagic gingivitis, abnormal tooth development, malnutrition, esophageal and urethral stricture.
8. The blister gradually decreases with age.
Diagnosis
Differential diagnosis
Clinical differential diagnosis:
1. Hereditary sclerosing cutaneous heterochromia.
2. Hereditary limb keratosis cutaneous heterochromia.
3. Congenital skin heterochromia.
4. Congenital keratosis.
