Changes in secondary sexual characteristics
Introduction
Introduction Secondary sexual change is a symptom of the clinical manifestations of dystrophic cirrhosis. Malnutrition cirrhosis is caused by chronic nutrient deficiencies. The cause of malnutrition, except for the lack of intake of individual patients, is mostly due to other diseases that limit the intake and absorption of food, such as the lack of cystine-containing protein after small intestinal bypass surgery, cysteine The decrease in the source of glutathione affects the production and activity of enzymes in hepatocytes, and the hepatocytes are damaged by various factors and undergo degeneration and necrosis.
Cause
Cause
Malnu tration Cirrhosis is caused by chronic nutritional deficiencies. Animal experiments have confirmed that simple malnutrition, especially protein, anti-fatty liver factors and B vitamin deficiency, can cause fatty liver, hepatocyte necrosis, degeneration and cirrhosis. The mechanism by which malnutrition leads to cirrhosis may be:
1 When a cystine-containing protein is lacking, the source of cysteine and glutathione is reduced, and the production and activity of the enzyme in the liver cell are affected, and the liver cell is damaged by various factors to cause degeneration and necrosis.
2 Choline is a fat-promoting substance, and it can synthesize phospholipids in the liver with neutral fat, so that the liver fat is easily oxidized and used. If the amino acids necessary for choline or synthetic choline are severely deficient, fat will accumulate in the liver cells and become fatty liver. Steatosis of hepatocytes can reduce the resistance of hepatocytes to various harmful factors, and can also squeeze and compress the hepatic sinus due to the increase of cell volume, gradually causing ischemia, necrosis, fibrous tissue hyperplasia and cirrhosis.
Examine
an examination
Related inspection
MRI examination of liver, gallbladder, pancreas and spleen by liver, gallbladder and spleen
Changes in sexual characteristics may occur 12 to 18 months after small bowel bypass surgery, such as decreased sexual desire, male breast development, female amenorrhea and secondary sexual characteristics. There is also loss of appetite, weakness, abdominal pain, nausea, vomiting. Signs of jaundice, hepatosplenomegaly, ascites, spider mites. The test showed elevated serum bile acid, elevated AST, normal ALT, prolonged prothrombin time, hypoalbuminemia, and liver biopsy showed hepatic steatosis and hepatitis.
Diagnosis
Differential diagnosis
Note the differentiation with other types of cirrhosis. Cirrhosis can occur in patients more than 7 years after small bowel bypass surgery. The formation of cirrhosis is hidden, clinical manifestations are not prominent, and occasionally die of cirrhosis and liver failure.
