Nodular hyperplasia of facial skin
Introduction
Introduction If the facial skin has nodular hyperplasia, it is more common in tumor-type leprosy, also seen in patients with lymphocytic leukemia. Tumor-type leprosy lesions: early skin lesions, usually spotted and diffuse infiltration. The etiology and pathogenesis of acute lymphocytic leukemia are not fully understood. The disease has extensive immature leukocyte proliferation in the bone marrow and enters the bloodstream, infiltrating and destroying other tissues.
Cause
Cause
Tumor-type leprosy
Skin lesions: early damage to the skin and mucous membranes, usually spotted and diffuse infiltration.
Acute lymphocytic leukemia
The etiology and pathogenesis are not fully understood. The disease has extensive immature leukocyte proliferation in the bone marrow and enters the bloodstream, infiltrating and destroying other tissues.
Examine
an examination
Related inspection
Physical examination of skin diseases
Symptom diagnosis:
First, the onset: Most patients have an acute onset, rapid progress, often with fever, anemia or bleeding as the first symptom. Some cases have a slow onset, with progressive anemia as the main performance.
Second, the symptoms:
(1) Anemia: There are anemias in the onset, but the severity varies.
(B) bleeding: Most patients have different degrees of bleeding in the course of the disease, with skin defects, ecchymosis, bleeding gums, nasal discharge is common. Severe cases may have visceral bleeding, such as blood in the stool, blood in the urine, hemoptysis and intracranial hemorrhage.
(3) Fever: It is one of the common symptoms of acute leukemia.
Third, physical signs:
(1) The liver, spleen and lymph nodes are swollen.
(B) bone and joint performance: bone and joint pain is a common manifestation, sternal tenderness has a certain value in the diagnosis of leukemia.
(C) other signs of infiltration: male testicular involvement can be diffuse enlargement, which is one of the causes of leukemia recurrence.
Fourth, central nervous system leukemia:
Table existing
1 Infiltration of the meninges can affect the circulation of cerebrospinal fluid, resulting in increased intracranial pressure, headache, nausea, vomiting, blurred vision, papilledema, abductor nerve paralysis and other phenomena.
2 Cranial nerve palsy is mainly the infiltration of nerve roots, especially through the third and seventh pairs of cranial nerve involvement at the cranial nerve hole.
3 The spinal cord is infiltrated by leukemia cells and is characterized by progressive paraplegia.
4 Infiltration of vascular endothelium and stasis of leukemia cells, secondary hemorrhage, clinical manifestations of cerebrovascular accidents.
Diagnosis
Differential diagnosis
Differential diagnosis of nodular hyperplasia in facial skin:
1. Subcutaneous nodules: Subcutaneous nodules are a hard, round or elliptical, painless nodule. The diameter is 0.2 to 10 cm. Often located in more parts of the friction, such as the elbow extension, the Achilles tendon, the scalp, the ischial tuberosity or around the joint. Unusual parts have ears and bridge of the nose. Subcutaneous nodules rarely cause symptoms, occasionally rupture or complicated infection. Typical subcutaneous nodules grow slowly, persist or disappear when the disease is relieved. The appearance of subcutaneous nodules is closely related to high titer serum rheumatoid factor, severe joint destruction and rheumatoid active lesions.
2, acne nodules: acne nodules refers to the appearance of acne in the thin and tender places of the skin, the emergence of large soybeans or mung beans. Acne is an inflammation of the skin caused by aphids in the epidermis of the human body. It is an infectious parasitic disease that can occur in any part of the human body.
Tumor-type leprosy
Skin lesions: early damage to the skin and mucous membranes, usually spotted and diffuse infiltration. It is characterized by small macules, multiple hairs, unclear borders, hypopigmentation or erythema, symmetric distribution, no sensory disturbances, often distributed in the trunk, face, limbs, buttocks. It must be examined under natural light, sometimes difficult under direct sunlight. It was found that nasal mucosal erosion can cause nosebleeds; as the disease progresses, the face can have diffuse infiltration, conjunctival hyperemia, and earlobe hypertrophy. There may be rashes, nodules, and fusion to form a lion's face. The most common sites of nodules are the earlobe, lower jaw, elbows, buttocks, knees, and back of the hands and feet.
