joint laxity
Introduction
Introduction Joint hyperactivity syndrome, also known as joint relaxation, is one of the causes of joint pain in the limbs, affecting the limbs' activities and functions. This disease is a hereditary disease. May be the result of a genetic disorder in connective tissue. There is no obvious gender difference in children with this symptom. Most of them are 2 to 3 years old and even learn to walk. There is joint relaxation. The pain often occurs in the lower extremity joints. The knee joints are especially common. The upper limbs, shoulders and elbow joints also occur. Generally bilaterally symmetrical, no joint swelling and limited mobility, more obvious after exercise. The pain is not very serious, but it is enough to affect the normal game and activities of the child.
Cause
Cause
It is one of the causes of joint pain in the limbs, affecting the limbs' activities and functions. This disease is a hereditary disease.
(1) Causes of the disease
May be the result of a genetic disorder in connective tissue.
(two) pathogenesis
At present, some scholars attribute this disease to Ehlers-Danlos syndrome type III, which has only joint relaxation, and no skin relaxation and other characteristics of Ehlers-Danlos syndrome. It has family tendency and dominant inheritance.
Examine
an examination
Related inspection
Arthroscopic examination of bone and joint soft tissue CT
There is no obvious gender difference in children with this symptom. Most of them are 2 to 3 years old and even learn to walk. There is joint relaxation. The pain often occurs in the lower extremity joints. The knee joints are especially common. The upper limbs, shoulders and elbow joints also occur. Generally bilaterally symmetrical, no joint swelling and limited mobility, more obvious after exercise. The pain is not very serious, but it is enough to affect the normal game and activities of the child.
Diagnosis
Differential diagnosis
In the differential diagnosis, the characteristics of several hereditary connective tissue diseases and Marfan syndrome, Ehlers-Danlos syndrome, rheumatic fever and some rare metabolic disorders such as homocystinuria may also have joint relaxation. However, this syndrome refers to the presence of systemic joint relaxation alone.
Marfan syndrome: Marfan syndrome is a hereditary disease with extensive connective tissue abnormalities, mainly involving the eye, bones and cardiovascular system, and is autosomal dominant. The incidence of this syndrome in children with older parents is significantly increased. Its main features are bilateral lens dislocation, slender finger (toe) and slender body type, which can have cardiac abnormalities and glaucoma.
Ehlers-Danlos syndrome: Congenital connective tissue hypoplasia syndrome was proposed by Ehlers (1901) and Danlos (1908), referring to a group of heredities with weak skin and blood vessels, excessive skin elasticity and excessive joint activity. Sexual disease.
Hypercysteine:
Hypercystinuria or homocystinuria, also known as pseudo Marfan syndrome, is one of the sulfur-containing amino acid metabolic diseases, which is an autosomal inherited metabolic disease. The mutant gene may be located on chromosome 2 short. Arms were first reported by Carson and Neill and Gerritsen et al. (1962). The incidence rate is 2.5/100,000 to 5/100,000 live infants. In addition to causing skeletal abnormalities and ocular lesions, this disease can cause vascular and brain lesions. Children with stroke should rule out the possibility of this disease.
