Bone marrow plasma cell increase
Introduction
Introduction Plasma cells are stimulated by antigens and converted into protoplasma cells. The protoplasmic cells are differentiated, propagated, and evolved into mature plasma cells through the stage of larval cells. Normally, plasma cells can only be seen in the bone marrow and not in circulating blood. The increase of bone marrow plasma cells is usually an abnormal increase of bone marrow plasma cells, and abnormal increase of bone marrow plasma cells may lead to bone marrow plasmacytoma. Such as high doses of ionizing radiation, chronic antigenic substance stimulation and viral infection, followed by viral infections, allergic diseases, connective tissue diseases, tuberculosis and other chronic infectious diseases, chronic liver diseases, malignant tumors and aplastic anemia, Hematopoietic diseases such as cell deficiency and myelodysplastic syndrome.
Cause
Cause
The cause is still unclear. Nowadays, humans only know some predisposing factors, such as high dose of ionizing radiation, chronic antigenic substance stimulation and viral infection, and family factors have also been reported.
Examine
an examination
Related inspection
Bone marrow plasma cell system bone marrow analysis of bone marrow hyperplasia degree Hb-F alkali degeneration test
Because the plasma cells of malignant hyperplasia will invade the bone marrow, it produces osteolytic lesions, clinical manifestations of bone pain, bone deformation or pathological fractures.
Diagnosis
Differential diagnosis
Can produce increased ESR, immune dysfunction, high monoclonal globulin (M protein), hypercalcemia; serum urea nitrogen, creatinine increased; X-ray examination, early visible osteoporosis, typical lesions are round Bone-like lesions of varying sizes, such as the size of the skull, pelvis, spine, femur, tibia, etc., pathological fractures are more common in the ribs, spine, clavicle, etc. (compressive fracture).
