cold erythema
Introduction
Introduction to cold erythema Cold erythema (colderythema) is a rare hereditary skin disease that causes abnormal reactions such as erythema and pain after cold stimulation, mainly involving the skin and digestive tract. Chinese medicine believes that this disease is not yang, and it is more cold-invasive. The blood is not running smoothly, the meridians are blocked, and the blood stagnates the skin. basic knowledge The proportion of illness: 0.001% Susceptible people: no specific population Mode of infection: non-infectious Complications: constipation
Cause
Causes of cold erythema
(1) Causes of the disease
Cold stimulation causes the body to have erythema, pain and other abnormal reactions. Hereditary biochemical defects may also be an important cause. Chinese medicine believes that this disease is not yang, and it is more cold, blood flow is not smooth, meridian barrier, blood stasis .
(two) pathogenesis
The pathogenesis is unclear, and it seems that platelet-bound serotonin disorder caused by hereditary biochemical defects causes the release of serotonin when the skin is stimulated by cold, resulting in a series of clinical symptoms.
Prevention
Cold erythema prevention
Focus on prevention, avoid contact with all cold stimuli, and if possible, move to a warm climate.
Complication
Cold erythema complications Complications constipation
At the same time with systemic erythema and hyperhidrosis, patients often accompanied by severe, refractory constipation.
Symptom
Cold erythema symptoms common symptoms severe pain constipation gastrointestinal symptoms collapse
After birth, there is an abnormal reaction to cold stimuli, mainly manifested as skin and gastrointestinal symptoms. When the skin is exposed to cold stimuli, such as contact with ice, local skin quickly appears large erythema, but no wheal, conscious local severe pain, erythema There is a sweating reaction in the center, which usually subsides slowly after 15 to 60 minutes. When the body is stimulated by cold in a large area, there may be systemic tendon and collapse. If the patient ingests cold food or drink, vomiting may occur, accompanied by systemic erythema and Excessive sweating, patients often accompanied by severe, refractory constipation.
Examine
Cold erythema check
Positive skin cold test: When the test, the water below 25 °C is contacted with the skin, it can produce short-term erythema, and the pain, the lower the water temperature, the more serious the local reaction, the abnormality of the tissue biopsy at the lesion, the patient is generally free of serological abnormalities. .
Skin biopsy at the lesion was not found abnormally.
Diagnosis
Diagnosis of cold erythema
After birth, there is an abnormal reaction to cold stimuli, mainly manifested as skin and gastrointestinal symptoms. When the skin is exposed to cold stimuli, such as contact with ice, local skin quickly appears large erythema, but no wheal, conscious local severe pain, erythema There is a sweating reaction in the center, which usually lasts for 15 to 60 minutes and then slowly subsides. When the body is stimulated by cold, the whole body tendon and collapse can occur, and the skin cold test is positive: the tissue biopsy at the lesion is not abnormal, and it can be diagnosed.
This disease is generally not confused with other diseases.
