skin lymphocytic infiltration
Introduction
Introduction to skin lymphocytosis Skin lymphocytic infiltration, also known as Jessner-Kanof syndrome, is a pseudocutaneous lymphoma of the skin. It is an inflammatory disease of the lymphatic network of the skin. It is characterized by papules and nodules that occur in the face. It often shows benign lymphoid cell proliferation, the pathogenesis is still unknown, may be related to insect bites, trauma, actinic, infectious factors, and sunlight can often induce or aggravate the disease. Immunohistochemical analysis showed that the infiltrating cells of most patients were CD8+ T lymphocytes. basic knowledge The proportion of illness: 0.025% Susceptible people: more common in men Mode of infection: non-infectious Complications: sepsis
Cause
Causes of skin lymphocytic infiltration
The cause is unknown. Some people think that this disease is a subtype of chronic discoid lupus erythematosus, while others think that this disease is a type 1 of skin lymphoma.
Prevention
Skin lymphocytic infiltration prevention
At present, the cause of this disease is not clear. Some people think that this disease is a subtype of chronic discoid lupus erythematosus. Therefore, patients with skin connective tissue disease should actively give long-term immunosuppressive therapy to avoid the occurrence of this disease. Secondly, early detection, early diagnosis and early treatment can alleviate the complications of this disease, and it is also important for the indirect prevention of secondary diseases.
Complication
Complications of cutaneous lymphocytic infiltration Complications sepsis
This disease is usually associated with lupus skin damage. This disease can cause skin rupture, so it can cause skin bacterial infection or fungal infection due to the destruction of skin integrity, usually secondary to low body constitution, or long-term use of immunosuppressants and Patients with fungal infections such as onychomycosis, such as concurrent bacterial infections, may have fever, skin swelling, ulceration, and purulent secretion. Severe cases can lead to sepsis, which should be brought to the attention of clinicians.
Symptom
Symptoms of lymphocytic infiltration of the skin Common symptoms Horns of the erythema outside the discoid erythema...
More common in men, often occurs in the upper face of the neck and trunk, the skin lesions start with small erythema, expanding to the surrounding, forming a red high plaque, the center often disappears, the boundary is clear, similar to discoid lupus, but the surface of the lesion Smooth, no follicular horn plug, no scar left after regression, no development of lupus erythematosus, lack of self-conscious symptoms.
Examine
Examination of skin lymphocytic infiltration
Histopathology: The epidermis is usually not affected, no hair follicle horn plug, and the dermis can be seen in the infiltrating of dense lymphocytes. The monoclonal antibody confirms that the lymphocyte infiltration is mainly T lymphocytes.
Diagnosis
Diagnosis and differentiation of skin lymphocytic infiltration
The disease needs to be differentiated from diseases such as swollen lupus erythematosus, facial granuloma, pleomorphic sun rash and cutaneous lymphoma. The main features of swollen lupus erythematosus are invasive, swollen erythema in the light, highly sensitive to light, complete remission after oral antimalarial treatment, no scarring, histological examination, perivascular and peri-glandular lymphocytes Infiltration and interstitial mucin deposition. The histological infiltrating cells of facial granuloma are mainly neutrophils and eosinophils. The rash of pleomorphic sun rash is pleomorphic and closely related to sunlight. Histological examination revealed a dermatological change in the epidermis. Lymphoid cells in the pathological lymphoma are more abnormal in morphology and form lymphoid follicles, which can be identified.
