Toxic Stun
Introduction
Introduction to toxic vertigo Viral bacterial infections, drugs, chemical poisoning, can induce dizziness, according to the cochlear and vestibular damage, morning and evening and different weight and performance, some with dizziness, and some with tinnitus, deafness. At present, drug poisoning, such as antibiotics, diuretics, anticancer drugs and other heavy metals such as lead and mercury, are most common, among which aminoglycoside antibiotics are most common, such as streptomycin, neomycin, kanamycin and Qing The poisoning caused by arsenic and the like is the most serious with streptomycin sulfate poisoning, accounting for about 12% of vestibular damage in China. Because it can interfere with and destroy cell protein synthesis, the vestibular terminal and nerve nucleus are destroyed, and even the cerebellum and brain stem are involved. Therefore, the severity of poisoning is not proportional to the amount of drug used, which may be related to individual susceptibility and renal function. basic knowledge The proportion of illness: 0.004% Susceptible people: no special people Mode of infection: non-infectious Complications: deafness, tinnitus
Cause
Toxic vertigo cause
Viral bacterial infections, drugs, chemical poisoning, can induce dizziness, according to the cochlear and vestibular damage, morning and evening and different weight and performance, some with dizziness, and some with tinnitus, deafness. At present, drug poisoning, such as antibiotics, diuretics, anticancer drugs and other heavy metals such as lead and mercury, are most common, among which aminoglycoside antibiotics are most common, such as streptomycin, neomycin, kanamycin and Qing The poisoning caused by arsenic and the like is the most serious with streptomycin sulfate poisoning, accounting for about 12% of vestibular damage in China. Because it can interfere with and destroy cell protein synthesis, the vestibular terminal and nerve nucleus are destroyed, and even the cerebellum and brain stem are involved. Therefore, the severity of poisoning is not proportional to the amount of drug used, which may be related to individual susceptibility and renal function.
Prevention
Toxic vertigo prevention
The prevention of this disease should be carried out according to the cause, due to the disease and the use of excessive side effects of drugs and infections and other toxins soaked in the blood system, so the clinical should be based on prevention, try not to use a small amount of toxic drugs, must be applied The cochlear vestibular function test can be performed weekly for monitoring. Once functional damage is found, it should be stopped in time. At the same time, the blood drug concentration should be tested. If the drug concentration is significantly higher than normal, the drug should be stopped.
Complication
Toxic vertigo complications Complications, deafness, tinnitus
Can be accompanied by complications such as tinnitus and deafness.
Symptom
Toxic vertigo symptoms Common symptoms Tinnitus visual recognition disorder vertigo dizziness nausea deafness drunk drug poisoning
There is a clear history of drug poisoning, and the general diagnosis is easier.
Pediatric symptoms are small and light, adults are heavier and more common, often complained of tinnitus, dizziness, nausea, vomiting, such as vestibular central involvement, there may be blurred vision, floating mosquitoes, heavy head movements are unclear After the head movement is stopped, the visual acuity is improved. The patient often walks straight and straight ahead, which is called Dadys syndrome. If the patient is not sensitive to drugs, it can appear after a large amount of medication. Symptoms, but the symptoms are not dizziness, but drunkenness, such as chronic poisoning, because the individual compensatory function is good, although the vestibular function is completely lost on both sides, and the patient is still unconscious, after the vestibular function test, if there is serious Functional damage, the degree of damage on both sides is asymmetrical, sometimes one side is serious and the other side can be normal. The temperature change test may have a dominant bias. The cochlear vestibule is not directly related to hearing damage. Sometimes the vestibule is seriously damaged and the hearing can be normal. Sensory neurological deafness of varying degrees.
Examine
Examination of toxic vertigo
Clinical physical examination: On the basis of the primary disease, there are sudden encephalitis-like manifestations, such as lethargy, convulsions, coma, convulsions, central paralysis, degenerative brain, pyramidal tract signs, etc., fundus examination may have papilledema. Brain symptoms can resolve within 1 to 3 days, without leaving sequelae, severe disease or treatment may be rapidly deteriorated, often with neurological damage sequelae.
Laboratory examination: Except for the increase of cerebrospinal fluid pressure, there was no obvious abnormality, and occasionally the protein was slightly increased. Head CT, MRI, EEG topographic map, etc.
Diagnosis
Diagnosis and diagnosis of toxic vertigo
diagnosis
Diagnosis can be based on medical history, clinical symptoms, and laboratory tests.
Differential diagnosis
1. Otogenic: The vestibular system is an important balancing organ of the human brain. The vestibular nucleus is sensitive to hypoxia, and vertigo is associated with its involvement. These diseases include Meniere's syndrome, vestibular neuronitis, and Auditory arterial occlusion, benign positional vertigo, motion sickness, etc.
2. Brain-derived: including vertebral-basal artery insufficiency, cerebellar pons lesions, autonomic disorders, etc., mostly related to age, after 50 years old, cervical vertebrae are prone to degeneration and osteophyte formation, arterial atherosclerosis The narrowing of the lumen of the blood vessel leads to a decrease in blood flow, which in turn affects the balance function associated with the brainstem and the cerebellum.
3. Systemic: including high blood pressure, low blood pressure, anemia, metabolic diseases, etc.
4. Cervical origin: the cause may have cervical degeneration, cervical and neck soft tissue lesions, neck tumors and skull base deformities, etc., causing compression of the vertebral artery, ischemia and vertigo, can be expressed in various forms Dizziness, but the occurrence is more related to the sudden rotation of the head, often accompanied by nausea, vomiting, ataxia and so on.
5. Ocularity: It usually occurs after the eye has been used for a long time or after a long time of gaze. After covering the affected eye or closing the eye, the vertigo can disappear, which can be caused by refractive error, eye muscle paralysis and vision loss.
6. Mentality: including insomnia, depression and so on.
