recurrent herpes
Introduction
Introduction to recurrent herpes Recurrent herpes is based on the infection of the virus, and under the influence of external incentives, the virus is activated and the disease occurs. Often occurs within 1 to 3 months after primary genital herpes. Patients with HSV-2 infection have a higher recurrence rate and a higher frequency of attacks. About 60% of patients relapse within 1 year after the first infection, and the number of episodes in the first year is 4 to 6 times, and some are as many as 10 or more. Lighter than primary genital herpes. basic knowledge The proportion of illness: 0.053% Susceptible people: no specific people Mode of infection: contact infection Complications: meningitis proctitis
Cause
Cause of recurrent herpes
1. Causes of recurrent herpes: On the basis of virus infection, under the influence of external incentives, the virus is activated and the disease occurs.
2, the cause of recurrence: fever, overwork, menstruation, rainforest, sun, cold, certain diseases and good infections (such as feeling).
Prevention
Recurrent herpes prevention
(1) Care for local damage should be kept clean and dry to prevent secondary infection;
(2) After the cure or recurrence, we must pay attention to prevent colds, cold, fatigue and other predisposing factors to reduce recurrence.
Complication
Recurrent herpes complications Complications meningitis proctitis
Caused a series of complications such as disseminated herpes, herpetic meningitis, prostatitis, proctitis, pelvic inflammatory disease, spinal nerve root disease. In areas where AIDS is endemic, the disease can also increase the risk of HIV infection.
Symptom
Symptoms of recurrent herpes common symptoms urinary tract burning sensation pruritus papules and pharyngeal burning sensation on the skin line...
The main symptoms are the burning of the affected part, and soon 3 to 10 clusters of red papules on the basis of erythema, accompanied by itching, the papules quickly become small blisters, and become pustules after 3 to 5 days. After the collapse, a large piece of erosion and ulceration is formed, consciously painful, and finally scarred. The entire course can last for about 20 days.
Examine
Examination of recurrent herpes
Cytological examination
Direct smear after the material is taken for Wright staining, Giemsa staining or Papanicolaou staining, which is helpful for diagnosis when eosinophilic inclusion bodies are found in the nucleus of multinucleated giant cells.
The sensitivity of this method is only 50% to 80%, and it is not specific. The positive rate of the disease is high at the early stage, and the positive rate is low at the later stage.
2. Pathogen examination
(1) HSV examination: The fluorescein-labeled anti-HSV-1 and anti-HSV-2 antibodies were used as direct immunofluorescence assays to distinguish HSV types.
(2) HSV antigen test: HSV antigen can also be detected by indirect immunofluorescence assay, enzyme-linked immunosorbent assay, Western blot assay or radioimmunoassay.
(3) HSV nucleic acid test: including nucleic acid probe detection method and nucleic acid amplification detection method, the latter is divided into PCR and LCR, and the sensitivity and specificity are strong, and it is fast and simple, and has low requirements on the detection material.
(4) HSV culture separation: commonly used cell culture method, mainly used for further identification of HSV.
(5) Electron microscopy: Take blister fluid or diseased brain tissue and observe the virus particles under electron microscope. The positive rate is 50%, but HSV is indistinguishable from other herpesviruses. Immunoelectron microscopy is more specific.
3. Serological examination
It is mainly used for detecting anti-HSV-1 and anti-HSV-2 antibodies, diagnosing primary infection of HSV, and conducting sero-epidemic investigation of HSV infection. Immunofluorescence assay, enzyme-linked immunosorbent assay, immunoblotting assay and radiation can be used. Immunoassay and other methods. In modern times, HSV-2 gD2 glycoprotein is used as an antigen to detect anti-HSV-2 antibodies, and HSV-1 gDl or gC glycoprotein is used as an antigen to detect anti-HSV-1 antibodies. The sensitivity is high and can be distinguished. Anti-HSV-1 and anti-HSV-2 antibodies, however, such tests can only indicate that the patient has developed a dominant or latent HSV infection.
Diagnosis
Diagnosis and diagnosis of recurrent herpes
diagnosis
The diagnosis of recurrent herpes infection is based on medical history, symptoms and skin or mucosal manifestations. It is generally not difficult to make a diagnosis. If necessary, laboratory tests can be performed to identify pathogens. Such as blister smear, culture, inoculation, immunofluorescence, serum immunoassay, etc., are helpful in diagnosing and determining the type of virus.
