rheumatic vasculitis
Introduction
Introduction to rheumatic vasculitis Rheumatoid vasculitis: a common systemic connective tissue disease characterized by non-suppurative polyarthritis. If extra-articular manifestations are the main clinical symptoms, such as pleurisy, myocarditis, pneumonia, neuritis and vasculitis, it is called malignant rheumatoid arthritis. Vasculitis is one of the pathologies of rheumatoid arthritis, and its various vascular lesions, most without symptoms, are only found at autopsy, so there is generally no clinical significance, but if multiple blood vessels occur (including medium arteries, arterioles, and Capillary inflammatory occlusion, the symptoms are obvious, and even death, is generally called rheumatoid vasculitis. Clinical manifestations of cutaneous vasculitis damage, localized can be affected by purpura, non-specific erythema of the trunk, vascular infarction, bullae and ulcers, 20% of patients with finger (toe) gangrene. basic knowledge The proportion of illness: 0.001% Susceptible people: no special people Mode of infection: non-infectious Complications: thrombosis
Cause
Causes of rheumatic vasculitis
Most of the causes are unknown, and a few causes are more clear, such as serum diseases, drug allergies and infections. Hepatitis B virus has been proven to be the cause of a variety of long-term vasculitis, and then found Chinese cytomegalovirus, herpes simplex virus, adult T-cell leukemia The virus can cause vasculitis.
The occurrence of primary vasculitis is mainly caused by immune abnormalities, while the research is more humoral immunity, and less research on cellular immunity. It is sensitized both endogenous and exogenous, with nuclear antigen, cryoglobulin and denaturing immunoglobulin in the endogenous; multi-drug and infectious factors in the exogenous antigen, but In most diseases, the cause is still not easy to determine.
Prevention
Rheumatoid vasculitis prevention
1. One egg at most one per day.
2, milk up to half a catty.
3. Eat more green vegetables.
4, kelp, seaweed, fungus eat more.
5, soy products + coarse grains to eat.
6, the spirit should relax, do not think about their patients every day.
7. To properly communicate with people.
8, absolutely can not smoke, drink, low-salt diet as well.
Complication
Rheumatoid vasculitis complications Complications thrombosis
The lesion may have thrombosis or aneurysmal expansion, and the healing lesion may have fibrous tissue and endothelial cell proliferation, which may lead to stenosis of the lumen.
Symptom
Rheumatoid vasculitis symptoms common symptoms fatigue skin purpura nodules erythema nodules vascular occlusion ulcer
Clinical manifestations of cutaneous vasculitis damage, limited access to purpura, non-specific erythema of the trunk, vascular infarction, bullae and ulcers, 20% of patients with finger (toe) gangrene. Capillary vasodilation, infarct papules and nodules occur in nail folds. Histopathological manifestations of leukocyte fragmentation vasculitis, also seen lymphocytic necrosis vasculitis. Invasion of blood vessels is different, and the condition is different. Intensive invading small and medium arteries has extensive systemic damage.
Examine
Rheumatoid vasculitis
Systemic signs and symptoms have moderate fever, fatigue, myalgia, joint pain, abdominal pain and/or gastrointestinal bleeding, pleurisy or pulmonary infiltration, pericarditis, mild proteinuria and hematuria, retinal hemorrhage, and central or peripheral nervous system Affected. Mainly for blood biochemical examination, histopathological examination.
Diagnosis
Diagnosis and diagnosis of rheumatic vasculitis
1, allergic purpura: occurs in children and adolescents, mostly in the lower extremities with ecchymosis, silt point is the most common skin lesions, may be associated with joint pain. Platelets are normal, urine can have proteinuria and hematuria, and occasionally gastrointestinal bleeding symptoms.
2, papular necrotizing tuberculosis rash: more common in young women, near the joints of the limbs or hips have scattered central necrotic solid papules, leaving atrophic scars after the recovery, tuberculin test is strongly positive, histopathology has tuberculosis tissue performance.
3, skin-type nodular polyarteritis: more in the lower limbs, there are subcutaneous nodules distributed along the small arteries, conscious pain and obvious tenderness, skin histopathological manifestations of arteritis and small arterial necrosis.
4, should also be associated with hyperglobulinemia, acute acne-like lichen-like pityriasis and nodular vasculitis.
