pemphigus herpetiformis
Introduction
Introduction to herpes-like pemphigus Herpesiform pemphigus (herpetiformpemphigus) refers to a clinical manifestation similar to herpes-like dermatitis, and histopathology shows the formation of epidermal vesicles and eosinophilic sponge, direct immunofluorescence to examine the disease of IgG deposition between epidermal cells. basic knowledge The proportion of illness: 0.002% Susceptible people: more common in middle-aged Mode of infection: non-infectious Complications: erythema pemphigus
Cause
Herpes-like pemphigus etiology
Pemphigus is an autoimmune disease. Anti-keratinocyte intercellular substance antibodies are present in the blood circulation of various pemphigus patients, and the antibody titer is parallel with the severity of the disease. The serum of pemphigus patients was added to the epidermal organ culture, and the spine release phenomenon appeared in the upper part of the basal cells after 48 to 72 hours. The occurrence of spine release may be related to the protease produced by antigen-antibody binding. It has been confirmed that the binding of pemphigus antibody to keratinocytes can release epidermal cells with plasminogen activator, which activates the fibrin system. Causes the spine to loosen. The pemphigus antigen is present in the keratinocyte-connected egg from the desmosome, which is a glycoprotein. The antigenic molecular weight of pemphigus vulgaris is 210000u (Dalton); the erythematous pemphigus antigen is desmoglein, molecular weight It is 160000u.
Prevention
Herpes-like pemphigus prevention
There is no preventive method for diseases of the immune system.
Complication
Herpes-like pemphigus complications Complications erythema pemphigus
A few cases can develop into erythematous pemphigus.
Symptom
Herpes simplex pemphigus symptoms Common symptoms Itching skin blisters or bullae damage erythema (clear boundary
Skin lesions were ring-shaped or multi-ring erythema, blisters, blister wall tension, Nissl's sign negative, with itching.
Examine
Herpes-like pemphigus examination
Histopathology and immunofluorescence.
Diagnosis
Diagnosis and diagnosis of herpes-like pemphigus
Diagnosis
1. More common in middle-aged and older, occurs in the chest, back, buttocks and proximal limbs. 2. Skin lesions are ring-shaped or multi-ring erythema, blister, blister wall tension, Nissl's sign negative, with itching. 3. Histopathology shows the formation of blisters and sponges in the middle of the spinous layer, eosinophil infiltration, and even small abscesses.
Differential diagnosis
1. Acute eczema: pleomorphic damage, tendency to exude, basically symmetric distribution, severe itching, chronic process and recurrent.
2. Herpes-like dermatitis: manifested as a blister-like blister-like cluster with itch. Histopathology showed subepidermal blisters, and the dermal papilla layer had microabscesses with neutrophil accumulation.
