primary cardiac lymphoma
Introduction
Introduction to primary cardiac lymphoma Primary cardiac lymphoma is a rare lymphoma. The world's anthology reports only 76 cases in 1949-1996 for more than 40 years. Some autopsy data indicate that the percentage of disseminated lymphoma involving the heart in autopsy materials is as high as 20%. . basic knowledge The proportion of illness: 0.005% Susceptible people: no special people Mode of infection: non-infectious Complications: heart failure, arrhythmia, myocardial infarction
Cause
Cause of primary cardiac lymphoma
Primary factor (75%):
Images of changes in the heart are: huge tumor mass; most small tumor nodules and diffuse infiltration, may be associated with pericardial effusion, and most of the cytological types are diffuse large cell lymphoma.
Other factors (25%):
Other types are also documented, some lesions are accompanied by amyloidosis, but there is no leukemia, the tumor cells must be differentiated from melanoma, undifferentiated carcinoma, granulocyte sarcoma and undifferentiated small round cell sarcoma. The B-cell immunophenotype is reported in the first, and the first case of primary cardiac lymphoma with T cell phenotype reported by Jensen et al in 1999. The results of immunocytochemistry are as follows: frozen section: CD2, CD45 Positive, CD3 minority positive, other CD1a, CD4, CD5, CD7, CD8, CD19, CD20, CD21 are negative, paraffin sections: CD3, CD45RO, CD43, CD74 positive; CD1, CD20, CD75, CD79a and TdT are Negative, but molecular biological examination showed inconsistency with the immunophenotype, showing the germline of TCR, JH rearrangement, non-clonality of VJ and TCR.
Prevention
Primary cardiac lymphoma prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Primary cardiac lymphoma complications Complications heart failure arrhythmia myocardial infarction
The disease is generally free of complications.
Symptom
Symptoms of primary cardiac lymphoma Common symptoms Upper limbs and facial blood vessels... Heart failure myocardial infarction pre-cardiac occult pain pericardial arrhythmia
Non-specific clinical manifestations, uncontrollable heart failure (52%); precordial pain (17%); arrhythmia (12%); pericardial tamponade (12%); superior vena cava syndrome ( 8%); myocardial infarction (1%), because the clinical manifestations are not characteristic, so the diagnosis is often established in the late stage of the disease, even when found in autopsy, the prognosis is very poor, the median survival time is 1 month, most The patient died after 2 to 3 weeks.
Examine
Examination of primary cardiac lymphoma
1. Myocardial biopsy shows lymphoma cells.
2. Cytological examination and immunophenotyping of pericardial effusion.
According to the condition, clinical manifestations, symptoms, signs, ECG, cardiac B-mode ultrasound, X-ray, myocardial enzymes and biochemical tests.
Diagnosis
Diagnosis and diagnosis of primary cardiac lymphoma
The clinical diagnosis of primary cardiac lymphoma is extremely difficult. Non-invasive examination can not make a clear diagnosis. The cytological examination of the pericardial effusion and the detection of immunophenotype are helpful for the establishment of the diagnosis, in the absence of pericardial effusion or product. In the case of a negative fluid test, a myocardial biopsy is required to confirm the diagnosis.
This disease is generally not confused with other diseases.
