Vaginal angiosarcoma
Introduction
Introduction to vaginal angiosarcoma Angiosarcoma (angiosarcoma), which occurs in the vagina, is rare, with an onset age of 18 to 86 years and a median age of 49 years. Mainly manifested as vaginal bleeding, may be associated with dysuria. The mass is located in the vaginal stump, the upper vaginal wall and the vaginal fornix. It is irregular induration, ranging from 2 to 8 cm in size. It may have ulcers on the surface and may infiltrate the vaginal wall. basic knowledge The proportion of sickness: 0.01% Susceptible people: women Mode of infection: non-infectious Complications: abnormal leucorrhea
Cause
Causes of vaginal angiosarcoma
(1) Causes of the disease
1. Viral infection Gessi et al (2002) used PCR, in situ hybridization and direct observation of virions under electron microscope to detect the presence of human herpes simplex virus-8 (HHV-8) in vaginal angiosarcoma, and considered HHV-8 infection and angiosarcoma Related to the occurrence.
2. Chronic stimulation 2 patients with vaginal epithelioid angiosarcoma have several years of vaginal pessary history.
3. There were 4 patients in the radiotherapy because of endometrial cancer, cervical adenocarcinoma, cervical squamous cell carcinoma, cervical squamous cell carcinoma and pelvic radiotherapy. After 9, 14, 20, 21 years, angiosarcoma appeared in the radiotherapy site, Morimura et al (2001) It is considered that the diagnosis of angiosarcoma caused by radiotherapy requires the exclusion of chronic lymphedema, and it must take place in the original radiotherapy site several years later.
(two) pathogenesis
The tumor is a blister-like or unclear plaque. The cut surface is purplish red, microcystic or spongy, and the boundary is unclear. The extent of infiltration seen under the microscope is far more than that seen by the naked eye.
Microscopic examination showed obvious dilated hemangioma-like cavities, which were irregular in size and shape, and formed an intricate sinus-like network. The red blood cells were visible in the lacunar space. The tumor cells proliferated in the basement membrane and could be attached to the inner wall of the blood vessel. Nodular protrusions in the lumen, tumor cells are mostly fusiform, undifferentiated in a polygonal shape, endothelium-like or epithelioid-like, nuclear atypia is obvious, mitotic figures are more common, and endothelial differentiation can be seen under electron microscopy, such as partially covering the base Membrane, cells tightly connected and swallowed vesicles, occasionally microfilaments, Weibel-Palade bodies, tubule structures, etc.
Immunohistochemical vascular endothelial markers F VIII, CD31, CD34 were mostly positive, and epithelioid angiosarcoma was also positive for low molecular keratin.
Prevention
Vaginal angiosarcoma prevention
1. Actively treat other diseases such as vaginal leukoplakia, chronic inflammation and ulcers.
2. Loose, breathable underwear should be worn in daily life, mainly based on pure cotton products, to avoid wearing underwear of chemical fiber products such as acrylic.
3. Vaginal tumors have irregular vaginal bleeding, vaginal discharge abnormalities, early diagnosis and active treatment.
Complication
Vaginal angiosarcoma complications Complications
Ulcer ulceration infection.
Symptom
Vaginal angiosarcoma symptoms Common symptoms Poor urination bleeding
Vaginal angiosarcoma is mainly characterized by vaginal bleeding, which may be accompanied by difficulty in urinating. The mass is located in the vaginal stump, the upper vaginal wall and the vaginal fornix. It is irregular induration, ranging from 2 to 8 cm in size. The surface may have ulcers and may infiltrate the vaginal wall. .
Examine
Examination of vaginal angiosarcoma
Tumor marker examination, secretion examination, histopathological examination. Colposcopy.
Diagnosis
Diagnosis and diagnosis of vaginal angiosarcoma
Vaginal angiosarcoma can be diagnosed based on clinical manifestations, symptoms and laboratory-related examinations. The diagnosis depends mainly on histopathological examination.
Epithelioid angiosarcoma should be distinguished from epithelioid sarcoma and metastatic carcinoma. Except for a small number of angioma-like images, epithelioid angiosarcoma endothelial markers are positive.
