Organochlorine pesticide poisoning
Introduction
Introduction to organochlorine pesticide poisoning Organochlorineinsecticide can enter the body from the respiratory tract, digestive tract and skin, and is mainly excreted by the kidneys. A small amount can also be excreted in the feces and milk. Because it is a fat-soluble substance, it has a special affinity for fat-rich tissues and can accumulate in adipose tissue. The poisoning mechanism of this class of insecticides is generally considered to be a chain reaction of dechlorination by the action of organochlorine molecules (chlorinated hydrocarbons) entering the blood circulation with oxygen-active atoms in the matrix, resulting in unstable oxygenates, which slowly decompose. , the formation of a new activation center, strongly acting on the surrounding tissue, causing serious pathological changes. basic knowledge The proportion of illness: 0.005%, the incidence rate of farmers is as high as 0.2% Susceptible people: no specific population Mode of infection: non-infectious Complications: coma, arrhythmia, respiratory failure
Cause
Organochlorine insecticide poisoning cause
Organochlorine insecticides can enter the body from the respiratory tract, digestive tract, and skin. They are mainly excreted by the kidneys. A small amount can also be excreted in the feces and milk. Because it is a fat-soluble substance, it has a special affinity for fat-rich tissues. Accumulated in adipose tissue, the poisoning mechanism of this class of insecticides is generally considered to be a chain reaction of dechlorination by the action of organochlorine molecules (chlorinated hydrocarbons) entering the blood circulation and oxygen-active atoms in the matrix, resulting in unstable oxygenation. The compound, which slowly decomposes, forms a new activation center, strongly acts on the surrounding tissue, causing serious pathological changes, mainly affected by the nervous system, liver, kidney and heart. Its main part of the nervous system toxic effect is brain movement. The central and cerebellum increase excitability, accompanied by cerebral cortex and autonomic dysfunction, and may also involve spinal nerves. For organs such as liver, kidney, and heart, it can promote dystrophic lesions, and also on skin and mucous membranes. Stimulating effect, 223 (DDT) has a mild estrogen-like response and has anti-steroidal effects.
Prevention
Organochlorine pesticide poisoning prevention
Such pesticides should be properly placed and prohibited from contact with food; when dispensing, the application should be strictly carried out according to the requirements. Do not play and work in the area where the pesticides are sprayed. After contacting this type of pesticide, immediately take off the clothes and take a bath with soapy water. , clear water shower.
Complication
Organochlorine insecticide poisoning complications Complications, coma, arrhythmia, respiratory failure
The main complications are epileptic seizures, coma, elevated body temperature, severe pulse rate, decreased blood pressure, arrhythmia, and even respiratory failure, renal failure, and sudden cardiac arrest.
Symptom
Symptoms of organochlorine pesticide poisoning Common symptoms Abdominal pain Blood pressure drop Mild poisoning Nasal nausea diarrhea Dizziness Sucking fatigue Allergic dermatitis
Poisoning of organochlorine pesticides usually occurs several hours after exposure to the drug. The initial symptoms are headache and dizziness, anxiety, fear, and may be emotional. In the future, there may be vomiting, weakness in the limbs, tremors in the hands, epileptic seizures, and the patient may lose the orientation of time and space, and then there may be convulsions. Usually die or recover within 1 to 3 days, the recovery has no sequelae or permanent disability.
Inhalation of poisoned patients by the respiratory tract with symptoms of eye and nose irritation, pharyngeal and laryngeal discomfort, throat, trachea, bronchitis, pneumonia, etc.; severe cough, spitting, hemoptysis, difficulty breathing, lung wet rales, etc. Signs of pulmonary edema; or nasal discharge. Skin contact may cause contact dermatitis or atopic dermatitis, sometimes with conjunctivitis or bronchial asthma. The timing and severity of symptoms of poisoning vary depending on the type of poison, dosage form, amount, and route of entry.
1, mild poisoning with headache, dizziness, fatigue, blurred vision, nausea, vomiting, abdominal pain, diarrhea, irritability and other central nervous system and digestive symptoms, occasionally muscle involuntary tics.
2. People with severe poisoning are mainly sweating, drooling, tremors, convulsions, hyperreflexia, tachycardia, purpura, and elevated body temperature.
3, severe poisoning can be epileptic seizures or clonic, tonic convulsions, occasionally in a violent and recurrent episodes of coma and respiratory failure, and even death. After repeated convulsions, there may be mental changes (such as forgetfulness, loss of orientation) or ataxia. Severe patients may have blood pressure drop, pulse frequency, arrhythmia or even ventricular fibrillation; or acute liver and kidney damage.
4, some preparations such as hexachlorocyclohexane and other poisoning, may have elevated blood sugar and blood calcium.
Examine
Inspection of organochlorine pesticide poisoning
After poisoning, the corresponding poison can be detected in the vomit or cleaning solution, blood sugar is increased, blood calcium is lowered, erythrocyte sedimentation rate is increased, liver and kidney function can be abnormal, and electrocardiogram can indicate multiple arrhythmia and myocardial damage. Sexual rhythm disorder, irregular slow waves appear.
Diagnosis
Diagnosis and identification of organochlorine pesticide poisoning
According to the medical history, clinical manifestations and laboratory data is not difficult to make a diagnosis.
Need to be identified with the following pesticide poisoning, organophosphorus pesticide poisoning, pyrethroid pesticide poisoning, formazan pesticide poisoning, organofluorine pesticide poisoning, the corresponding poison can be detected in the vomit or cleaning solution after poisoning, can be identified.
