Chronic bullous disease in children
Introduction
Introduction to chronic bullous disease in children Chronic bullous disease of childhood is a chronic non-hereditary bullous skin disease in children, which is more common in children in Asia and Africa than in Western countries. The disease is similar to the linear IgA bullous skin disease in children. Its clinical manifestation is similar to juvenile pemphigus. Immunopathology shows IgA linear deposition along the basement membrane zone, and no IgG or IgA is detected in the serum. The immunological test should be repeated at intervals of 2 to 3 weeks, and can be treated with corticosteroids and dapsone. basic knowledge The proportion of illness: 0.001% Susceptible people: children Mode of infection: non-infectious Complications: swelling
Cause
Causes of chronic bullous disease in children
Cause:
It is a chronic non-hereditous bullous skin disease in children with unknown etiology.
Pathogenesis
The disease is the same as linear IgA bullous skin disease in children. Its clinical manifestation is similar to juvenile pemphigus. Immunopathology shows IgA linear deposition along the basement membrane zone. IgG or IgA is not detected in serum. The immunological test was repeated at intervals of 2 to 3 weeks.
Prevention
Prevention of chronic bullous disease in children
There is nothing too much to pay attention to, mainly to supplement the nutrients needed in the body. Explain the importance of nutrition therapy to patients and their families, and formulate a reasonable and detailed diet plan, focusing on high-protein and high-vitamin foods such as milk, eggs, lean meat, vegetables, fruits, etc., based on the healing of the patient's oral mucosa. The semi-liquid gradually transitions to general food, and more foods containing high potassium. Bullous pemphigoid is mostly caused by autoimmune disorders, so it is necessary to effectively prevent the effects of cross-reactive foreign antigens or eliminate various factors affecting the changes of autoantigens, such as preventing infectious diseases. The occurrence of active treatment of infectious diseases reduces the impact on the immune system, avoiding the use of certain drugs that easily induce autoimmune reactions.
Complication
Complications of chronic bullous disease in children Complications swelling
The disease may be accompanied by severe itching, and the integrity of the skin is destroyed, so it may cause skin bacterial infection or fungal infection due to scratching, usually secondary to low constitution, or long-term use of immunosuppressive agents and fungal infections such as nail fungus. Patients, such as concurrent bacterial infections, may have symptoms such as fever, swelling of the skin, ulceration, and purulent secretion. Severe cases can lead to sepsis, which should be brought to the attention of clinicians.
Symptom
Symptoms of chronic bullous disease in children Common symptoms Blisters or bullae damage herpes pruritus (with purulent liquid)
Small blisters and bullae occur around the mouth and vulva, and some are ring-shaped or herpes-like, with no gluten allergic bowel disease, consciously itchy and itchy.
Examine
Examination of chronic bullous disease in children
Histopathology: for the epidermis blister, part of the nipple and normal skin junction can be seen at the nipple microabscess.
Diagnosis
Diagnosis and diagnosis of chronic bullous disease in children
According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed.
According to the clinical features of the disease and the appearance of the skin, it should be differentiated from the following diseases.
1. Juvenile pemphigus: skin damage can be divided into bullous, vesicular, erythema and localized. The children are mainly vesicular and bullous, and the basic damage is tension vesicles and bullae with a diameter of about 0.5cm. The maximum diameter is up to 7cm. The blister wall is thick and tense. The Nissl's sign is negative, the blister is clear, and even bloody. , occurs on the basis of normal skin or erythema. Occurs in the trunk and the extremities. About 25% of patients have mucosal damage, which can cause blisters and erosions in the mucous membranes of the mouth, pharynx, vulva and perianal.
2. Juvenile herpes-like dermatitis: The basic lesions are blistering and bullae that are arranged in a ring or cluster on the basis of erythema, with a diameter of 0.3-1.0 cm. The blister wall is thick and tense, the blister fluid is clear, and the lesion is Nissian. negative. Occurs in the extremities of the extremities, shoulders and back and lumbosacral. The mucous membrane is rarely affected, and it can also express erythematous papules and urticaria.
