Anhidrosis
Introduction
Introduction to no sweat Anhidrosis refers to the surface of the skin with less sweat or no sweat at all, also known as sweat closure, which can be divided into localized sweat closure or body sweat closure, which belongs to the scope of Chinese medicine "closed". Causes of no sweating may include sweat gland dysfunction and nervous system damage, and other conditions may also cause no sweat. The types include neuropathic sweatlessness, sweat gland dysfunction, sweatlessness, and idiopathic sweatlessness. basic knowledge Sickness ratio: 0.0001% Susceptible people: no special people Mode of infection: non-infectious Complications: scleroderma
Cause
Cause of no sweat
(1) Causes of the disease
Hyperhidrosis can cause idiopathic sweating due to sweat gland dysfunction and nervous system damage, as well as other conditions.
Neural pathway dysfunction (30%):
Caused by dysfunction of the neural pathway that activates the sweat gland. For example, medullary damage can cause ipsilateral segmental sweat closure or impair temporary sweating in the following areas. Systemic sweating caused by disease may be caused by increased inhibition of the hypothalamus by the cortex. Hypothalamic tumors or damage to the third ventricle can also result in no sweat and high fever throughout the body. The lower brain stem disease can cause ipsilateral facial and neck sweatlessness. Heatstroke and high fever can also cause transient sweating, which may inhibit the hypothalamus, causing a lack of central nervous nerve impulses in the sweat glands and causing no sweat. Leprosy, alcoholic neuritis, amyloidosis, diabetes, gout can occur without sweat, may be due to the above diseases caused by ganglion block and segmental sweat. Hyperhidrosis can occur in autonomic neuropathy, ganglion block, Horner syndrome, type IV hereditary sensory neuropathy, and cholinergic drugs.
Sweat gland hypoplasia (25%):
Found in congenital ectodermal dysplasia. The patient's sweat gland hypoplasia leads to generalized hyperhidrosis, and is associated with hypoplasia or incompleteness of various aspects of sebaceous glands, hair, and nails. Acquired sweatlessness is seen in scleroderma, tumors, burns, skin grafts, radiation dermatitis, lymphoma, Sjogren syndrome, and chronic atrophic acral dermatitis, and can even cause sweating of small sweat glands to disappear. Some drugs cause sweat gland destruction can also produce non-perspiration, such as mipalin (Api), atropine and scopolamine anti-cholinergic drugs, barbiturate and diazepam cause sweat gland necrosis and lead to no sweat.
Skin keratinization (18%):
Miliary rash and sweaty tube obstruction caused by inflammatory and keratotic skin diseases, sweat remains in the skin, and there is no sweating. The common clinical manifestations of miliary rash are white peony, red sputum, purulent sputum, and deep sputum. Ichthyosis, psoriasis, pemphigus, sweat keratosis and atopic dermatitis, as well as seborrheic dermatitis can block the sweat flowing in the sweat tube and cause sweatlessness. Zirconium salts, aluminum salts, formaldehyde, glutaraldehyde and iontophoresis can also occlude local sweat pores.
Other factors (15%):
Neonatal and premature infants have impaired neurodevelopment, no sweat for several weeks after birth; patients with hypothyroidism, tumors, uremia, cirrhosis, endocrine diseases (such as Addison's disease, diabetes, etc.) and rare genetic diseases (such as Fabry) Sudden sweating can occur in diseases, Franceschetti-Jatassohn syndrome, etc., and radiant heat and gypsum tube type compression can also cause temporary sweating.
(two) pathogenesis
The dysfunction of the sweat glands, damage to the nervous system, and other diseases cause sweat gland dysfunction, resulting in less sweat or no sweat on the surface of the human skin.
Prevention
No sweat prevention
Hyperhidrosis can cause idiopathic sweating due to sweat gland dysfunction and nervous system damage, as well as other conditions. The etiology of this disease is not clear, and may have certain correlation with environmental factors, genetic factors, dietary factors, and mood and nutrition during pregnancy. Therefore, it is impossible to directly prevent the disease against the cause. Early detection, early diagnosis, and early treatment are important for indirect prevention of this disease.
Complication
No sweat complications Complications scleroderma
Acquired sweatlessness is seen in scleroderma, tumors, burns, skin grafts, radiation dermatitis, lymphoma, Sjogren syndrome, and chronic atrophic dermatitis. Leprosy can occur in leprosy, alcoholic neuritis, amyloidosis, diabetes, and gout. Patients with hypothyroidism, tumors, uremia, cirrhosis, endocrine diseases (such as Addison's disease, diabetes, diabetes insipidus), and rare genetic diseases (such as Fabry's disease, Franceschetti-Jatassohn's syndrome, and Helweg-Larssen's syndrome) There is no sweating.
Symptom
No sweat symptoms Common symptoms Fatigue heart rate increases, virtual tides, red tides, dry skin, sweating, abnormal heat stroke
1. The patient's whole body skin or a certain part has no obvious sweat all year round. Patients with systemic sweatlessness often feel general malaise, extreme fatigue, and most obvious during exercise. During the hot weather season, body temperature tends to increase, heart rate increases, body skin Flushing, and even symptoms such as collapse, heat stroke and so on.
2. Localized skin is dry, rough, or appears on some skin lesions, and the symptoms are mild.
3. Sweating experiments can be determined.
Examine
No sweat test
Clinical skin examination: There is no obvious sweat in the whole body skin or part of the patient throughout the year. Localized skin is dry, rough, or appears on some skin lesions, and the symptoms are mild.
Clinical pathology: specimen biopsy was found to be sebaceous gland-like tissue, and there was no sweat gland duct, or a large number of oil droplets were seen to block the sweat gland duct, and the base was swollen.
Other tests: sympathetic function tests.
Diagnosis
No sweat diagnosis diagnosis
Hyperhidrosis should distinguish certain skin diseases from the following diseases, such as severe ichthyosis, scleroderma, leprosy, radiation dermatitis, skin atrophy, etc., which can cause limited sweating.
Nerve injuries, such as transverse myelitis, poliomyelitis, paraplegia, and local damage to the sympathetic, medullary, and pons, can cause systemic or limited sweating.
Some visceral disorders, such as diabetes, diabetes insipidus, chronic nephritis, myxedema, malignant tumors, etc., in addition, vitamin A deficiency, etc., can also cause systemic sweat.
