hypervitamin A disease
Introduction
Introduction to vitamin A excess disease Vitamin A is a fat-soluble vitamin associated with bone growth, epithelial tissue metabolism and regeneration, and storage of retinal rhodopsin. Vitamin A can interfere with the metabolism of chondrocytes, affect the synthesis of chondroitin sulfate, and also enable subperiosteal bone. Increased quality, fibrosis of the medullary cavity adjacent to the cancellous bone. Large doses of vitamin A can increase bone skeletal cells in mice, increase bone resorption, and are prone to fracture. basic knowledge The proportion of illness: 0.003%--0.005% Susceptible people: no special people Mode of infection: non-infectious Complications: fracture
Cause
Causes of excessive vitamin A disease
Long-term large-scale supplementation of vitamin A, or long-term treatment of skin diseases with large doses of vitamin A, such as ichthyosis and some hyperkeratotic skin diseases, can occur chronic poisoning, such as daily intake of vitamin A 50,000 ~ 500,000 IU or more, can be poisoned symptom.
Prevention
Vitamin A overdose prevention
Promote universal knowledge of nutrition and hygiene, correct parents' abuse of vitamin A preparations and bad eating habits. For example, animal liver is an organ that stores vitamin A. It is rich in nutrients, but it is not suitable for eating every day. Food should be varied. Prevent the occurrence of iatrogenic vitamin A poisoning.
Complication
Vitamin A overdose complications Complications
Acute poisoning can lead to death and fractures.
Symptom
Symptoms of vitamin A overdose common symptoms alopecia hepatosplenomegaly dry skin increased intracranial pressure nausea sleepiness long bone swelling pain
1. Acute poisoning: The systemic manifestations of acute poisoning patients have symptoms of increased intracranial pressure, headache, lethargy, nausea and vomiting, and even death.
2. Chronic poisoning: Chronic poisoning shows hepatosplenomegaly, hair loss, dry skin and long bone swelling and pain.
Examine
Excessive vitamin A examination
Laboratory examination: The patient's plasma vitamin A content was significantly increased.
X-ray: showing new bone formation under the periosteum of the long bone and cartilage destruction.
Diagnosis
Diagnosis and identification of vitamin A excess disease
Diagnosis can be established based on medical history, clinical manifestations, X-ray examination, and laboratory examination.
The periosteum of the disease is sometimes similar to the infant's cortical hyperplasia, but the latter has a thicker cortical thickening and the mandible is also invaded. The ankle is not invaded and can be distinguished from ankylosing spondylitis.
