Vulvar verrucous xanthoma
Introduction
Introduction to vulvar jaundice Vulvar jaundice is a benign tumor that occurs in the oral mucosa and external genital organs. Clinically rare. It was first described and named by Shafer in 1971. The incidence rate is about 0.046%. Caucasians are more susceptible to blacks, and almost all ages can be affected without gender differences. basic knowledge The proportion of illness: 0.0025% Susceptible people: women Mode of infection: non-infectious Complications: urinary tract infection
Cause
Causes of vulvar sputum xanthomas
Causes:
The etiology of sickle xanthoma has not been known so far, and may be related to inflammation, virus, bacterial or fungal infection, local irritation, etc. Some scholars have found that this disease often has other lesions in the lesion, such as epidermal sputum with infection. Squamous cell carcinoma, oral mucosal carcinoma in situ, and even lesions have suffered from pemphigus vulgaris.
Epidermal proliferation theory, foam cell infiltration theory:
The pathogenesis of vulvar jaundice is epithelial proliferation theory, foam cell infiltration theory and the different doctrines of mutual growth. The former believes that the disease occurs in local susceptible areas, and neutrophil infiltration appears in the epidermis. See bacterial infection, leading to epidermal proliferation and degeneration, so that lipid droplets in epithelial cells enter the dermal papilla, which causes foam cellization of macrophages. The latter believes that certain causes of dermal papilla cause accumulation of foam cells, followed by nipples on the epidermis. Tumor-like hyperplasia.
feature:
The characteristics of the sacral xanthoma under the light microscope are: epithelial hyperplasia of the epidermis or mucosa, and the epithelial surface often shows three forms: 1 papillary hyperplasia; 2 scorpion hyperplasia; 3 epithelial to connective tissue deep hyperplasia, and the surface is flat These three forms of epithelial surface are hyperkeratotic and keratotic, and the keratinized layer is often deeply trapped in the deep epithelium. The epithelial nuclear debris and scattered neutrophils can be seen in the epithelial keratinization. Infiltration, epithelial nailing widens, regular growth into connective tissue, dermal papillae between the epithelial spikes, and the dermal papillae and collagen fibers are filled with large, round or polygonal foam cells (or It is called a xanthoma cell, and its boundary is clear. The cytoplasm is rich in foam, the nucleus is small, and the nucleus is deep-stained. It is located in the center of the cell. The collagen fiber can be hyaline degenerated. There are few foam cells in the tissue below the epithelial nail. There may be chronic inflammatory cell infiltration.
Prevention
Vulvar jaundice prevention
Pay attention to genital hygiene, regular physical examination, early diagnosis, active treatment, and good follow-up.
Usually pay attention to menstrual hygiene, pay attention to avoid sex during treatment, do not wear too tight underwear, do not use drugs on their own, do a good rest.
Diet should be light, avoid spicy, irritating food.
Complication
Vulvar jaundice Complications, urinary tract infections
The disease can cause ulceration of the skin and mucous membranes of the vulva, thereby secondary infection of the vulva or urinary tract.
Symptom
Symptoms of vulvar jaundice X-ray common symptoms Symptoms of pubic lumps can be horny
Sickle xanthomas occur in the oral mucosa and vulva, which occurs in the female genital area mainly invading the labia, vagina, and skin lesions as isolated chronic growth lesions. The appearance is scorpion-like, papillary, disc-shaped flat bulge or granular. With pedicle or no pedicle, the boundary is clear, the color can be normal skin color, light red, brownish yellow, light yellow or grayish white, the maximum diameter is generally less than 2cm, but the larger one can reach 4cm, the growth is slow, without any discomfort or slight touch Pain, the average duration of disease is several months, up to 30 years.
Examine
Examination of vulvar jaundice
Tumor marker examination, blood routine examination. Histopathological examination.
Histopathological examination: A pathological morphological method used to examine pathological changes in organs, tissues or cells of the body. In order to investigate the pathogenesis of organs, tissues or cells, a pathological examination method can be used to examine the pathological changes, to explore the causes, pathogenesis, pathogenesis and development of the lesions, and finally to make pathology. diagnosis. Pathological morphology examination method, first observe the pathological changes of the gross specimen, and then cut a certain size of the diseased tissue, pathological histological method to make a pathological section, further examination of the lesion with a microscope.
Diagnosis
Diagnosis and diagnosis of vulvar jaundice
Vulvar jaundice can be diagnosed based on clinical manifestations, symptoms, and histopathological examination.
Vulvar sputum xanthomas must be differentiated from female genital warts, common warts, and sickle cancer.
