Vulvar adenosquamous carcinoma
Introduction
Introduction to vulvar adenosquamous carcinoma Vulvar adenosquamous carcinoma is called pseudoadenospermous carcinoma. It is a bidirectionally differentiated epithelial carcinoma. The squamous cell carcinoma and adenocarcinoma components and intermediate components can be seen by electron microscopy. The prognosis seems to be worse than that of general squamous cell carcinoma. basic knowledge Sickness ratio: 0.0001% Susceptible people: no special people Mode of infection: non-infectious Complications: lymphatic tuberculosis
Cause
Etiology of vulvar adenosquamous carcinoma
(1) Causes of the disease
DNA of HPV (human papillomavirus) has been found in adenosquamous carcinoma, suggesting that vulvar squamous cell carcinoma is associated with human papillomavirus infection.
(two) pathogenesis
The cancer contains squamous cell carcinoma and adenocarcinoma, which is a bidirectionally differentiated epithelial cancer. It is derived from the vestibular gland or an apomictic embryonic tissue. The squamous cell carcinoma and glandular epithelial cells are seen under the microscope and are still in The intermediate type between the two, squamous epithelial cancer cells can be low-differentiation spindle cells, glandular epithelial cells contain mucus, PAS and mucus cardin red reaction positive, some cells contain glycogen under electron microscope; some have microvilli The cells contain mucous vacuoles, descaling under the microscope, and there are transitional cell components outside the glandular component. The latter can be explained by differentiation of the vestibular gland, acupoint anal or urogenital sinus residual naive tissue to the urinary or intestinal epithelium.
Prevention
Vulvar squamous cell carcinoma prevention
Do a good job in prevention and treatment according to the third-level prevention of cancer. Pay attention to rest, work and rest, life in an orderly manner, and maintaining an optimistic, positive and upward attitude towards life can be of great help in preventing diseases.
Complication
Vulvar squamous cell carcinoma complications Complications, lymphatic tuberculosis
After the ulcer is formed, it is easy to be infected, and the rate of inguinal lymph node metastasis is high.
Symptom
Vulvar glandular squamous cell carcinoma common symptoms repeated bleeding itching
No specific clinical manifestations, there may be itching, skin ulceration accounted for a small number, ulceration can be seen, vulvar squamous cell carcinoma treatment time is later.
Examine
Examination of vulvar squamous cell carcinoma
Vaginal secretion examination, polymerase chain reaction of human papillomavirus, tumor marker examination.
Histopathological examination.
Diagnosis
Diagnosis and differentiation of vulvar adenosquamous carcinoma
According to clinical manifestations, physical signs and experimental examinations can be diagnosed, but the diagnosis should be based on biopsy.
It should be differentiated from vulvar eczema and external superficial ulcer.
