Malignant fibrous histiocytoma of the vulva
Introduction
Introduction to vulvar malignant fibrous histiocytoma Vulvar fibrous histiocytoma is the most common soft tissue sarcoma in middle-aged and elderly people. It is a pleomorphic sarcoma. It is mostly found in the limbs of the elderly. It is rare in the vulva. Some cases were previously diagnosed as pleomorphic liposarcoma, fibrosarcoma. Or rhabdomyosarcoma, now belongs to this disease. Tumor size, especially tumor depth, is highly dependent on survival. basic knowledge The proportion of illness: 0.005% Susceptible population: the most common in middle-aged Mode of infection: non-infectious Complications: genital itching
Cause
The cause of vulvar malignant fibrous histiocytoma
Cause:
Vulvar malignant fibrous histiocytoma is derived from undifferentiated mesenchymal cells.
Pathogenesis
The tumor is a nodular or lobulated mass with clear boundaries, no true envelope, infiltration and growth around the surface, grayish gray, gray-red or gray-yellow, with hemorrhage, necrosis, mucus or cystic changes.
Microscopic examination of tumor invasive, often invading surrounding fat, fascia, muscle and peri-glandular tissue, a variety of cell morphology, the main components are fibroblast-like cells and tissue-like cells, and different differentiated mesenchymal cells can be seen. Muscle fibroblasts, etc., with varying numbers of mononuclear and multinucleated giant cells, yellow tumor cells, foam cells and various inflammatory cells, the nuclear and cytoplasm of various tumor cells vary greatly, grotesque, and mitotic figures are common. Some areas of fibroblast-like cells are arranged in a car-like or mat-like shape, occasionally arranged in bundles or diffusely distributed, mainly car-like-polymorphic, giant cell type, mucinous type, inflammatory and hemangiomas. Sample and so on.
Prevention
Vulvar malignant fibrous histiocytoma prevention
1, regular physical examination and do a good level of prevention of cancer patients.
2, quit smoking
By smoking or using tobacco in any way, it can cause cancer, and 90% of lung cancer is caused by tobacco. Smoking indirectly causes oral cancer, nasopharyngeal cancer, laryngeal cancer, esophageal cancer, pancreatic cancer, cervical cancer, kidney cancer and bladder cancer. Quitting smoking is the easiest and least expensive way to reduce the risk of cancer.
3. Reasonable meal
Choose healthy foods and beverages instead of high-fat, high-sugar and high-calorie foods, eat different types of vegetables, fruits, whole grains and legumes, reduce the consumption of red meat (beef, pork and lamb), and avoid processed meat. Class, limit the consumption of high-salt foods.
4, balance mentality, mental health
Mental health is a good medicine to overcome the disease, and bad mood may be a cancer-promoting agent.
Complication
Vulvar malignant fibrous histiocytoma complications Complications, genital itching
Infection of the lesion, occasionally involving the vulva and vagina.
Symptom
Vulvar malignant fibrous histiocytoma symptoms common symptoms shame mass
Vulvar malignant fibrous histiocytoma is more common in the labia majora. Most of them show painlessness. The active subcutaneous mass can also be expressed as a huge mass protruding rapidly. The size is (2×2.5) cm(12×5). Cm, can be associated with surface skin ulcers, can be divided into 2 types, that is, shallow type and deep type, shallow type can reach the fascia, but mostly limited to subcutaneous tissue, very few can also invade superficial skin and break Deep in the tumor or completely in the muscle, or from the subcutaneous tissue through the fascia into the muscle, deep in the tumor than in the shallower one-fold, the deep-year survival rate is significantly reduced, the two are 40% and 65% respectively In addition to local lymph node metastasis, lung metastasis is also common. It is a common cause of death. The tumor is usually quite large. Because of its unclear state, it is believed that even if the resection size is sufficient, nearly half of the recurrences occur.
Examine
Examination of vulvar malignant fibrous histiocytoma
Histochemistry and immunohistochemistry: 1 anti-pancreatin protein and 1 antichymotrypsin were positive for peroxidase staining, immunohistochemistry had no specific markers, most Vimentin, AACT, CD68, Lysozyme positive, partial Desmin Positive, and S-100 is negative.
Histopathological examination.
Diagnosis
Diagnosis and diagnosis of malignant fibrous histiocytoma of vulva
According to clinical manifestations, signs and laboratory tests and histopathological examination to confirm the diagnosis.
Pathologically, it should be distinguished from atypical fibroma, which has a small lesion, originates from the dermis, has no tendency to invade deep tissues, and has a vortex-like structure in malignant fibrous histiocytoma, but not in atypical fibrous xanthoma. phenomenon.
