clear cell acanthoma
Introduction
Introduction to clear cell acanthoma Clearcellacanthoma (clearcellacanthoma), also known as palecell Acanthoma (PalecellAcanthoma) was first reported by Degos et al in 1962, so it is also known as Degos acanthoma. The typical lesion is a localized brown moist smooth nodule, which usually develops after 40 years of age. basic knowledge Sickness ratio: 0.05% Susceptible people: no specific population Mode of infection: non-infectious complication:
Cause
Cause of acellular acanthoma
(1) Causes of the disease
The cause is unknown.
(two) pathogenesis
The pathogenesis is still unclear.
Prevention
Transparent cell acanthoma prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Transparent cell acanthoma complications Complication
Symptom
Clear cell acanthoma symptoms common symptoms crusted scaly nodules
Typical skin lesions are localized brown moist smooth nodules with clear boundaries and crusting on the surface. The circumference can be attached to collar-like scales, usually about 1 to 2 cm in diameter. The pressure can fade, and it occurs in front of the ankle. Department, even in the thigh, abdomen and scrotum, skin lesions are often single, but most of the occurrence, rare rash type lesions can be more than 400, slow growth, no symptoms, mostly after 40 years old Onset, there is no report of secondary squamous cell carcinoma.
Examine
Examination of clear cell acanthoma
Histopathology, the lesion is located in the epidermis, the epithelial layer is hypertrophic, the keratinocytes are pale, transparent, and the enlargement is polygonal. The boundary between the adjacent normal epidermal cells is clear, the basal layer is normal, and the transparent keratinocytes are rich in glycogen and lack phosphoric acid. The enzyme, cytoplasmic cytochrome oxidase and succinate dehydrogenase content decreased, visible sponge formation, epidermal extension can be fused, occasionally psoriatic hyperplasia, lack of granular layer, visible neutrophil infiltration, stratum corneum angle Incompleteness with effusion, lack of pigment in the epidermis and basal layer.
Diagnosis
Diagnosis and diagnosis of acellular acanthoma
According to clinical manifestations, typical lesions can be diagnosed by histopathology.
The disease should be differentiated from small sweat glandular bronchoma and clear cell sweat adenoma. The former often occurs in the hairless part of the foot, and the latter occurs in the head, especially the face and eyelids.
