idiopathic skin calcification
Introduction
Introduction to idiopathic skin calcification Calcinosiscutis is a disease caused by the deposition of insoluble calcium salts (mainly undetermined calcium phosphate or small amounts of calcium carbonate) in the skin or subcutaneous tissue. It can be divided into metastatic skin calcification, malnutrition calcification and special hair. Type 3 such as sexual calcification. basic knowledge The proportion of illness: 0.0021% Susceptible people: no specific population Mode of infection: non-infectious complication:
Cause
Idiopathic skin calcification etiology
(1) Causes of the disease
It is a disease caused by deposition of insoluble calcium salts (mainly undetermined calcium phosphate or a small amount of calcium carbonate) in the skin or under the skin.
(two) pathogenesis
Calcium deposits in previously damaged tissues, serum calcium and phosphorus levels are normal, internal organs are not invaded, and the pathogenesis is still unclear.
Prevention
Idiopathic skin calcification prevention
Treat the underlying disease as much as possible and not abuse the vitamin D preparation.
Complication
Idiopathic skin calcification complications Complication
Symptom
Symptoms of idiopathic skin calcification common symptoms skin calcium calcification abdominal wall extensive calcium deposition subcutaneous nodules papules
Can be divided into mass calcification and subepidermal calcification nodules.
Massive calcification
It has many large subcutaneous calcified masses, which can be associated with papular and nodular calcified skin lesions. This disease often has a family history and complicated hyperphosphatemia.
2. Subepidermal calcified nodule
Also known as skin stones, usually a single small bulging hard nodules, sometimes 2 to 3 nodules, the surface of the nodules are mostly scorpion-like, but the surface can also be smooth, common parts are facial, some cases have many Or even countless nodules, most of the patients are children, some cases have individual nodules at birth or no nodules before adulthood.
Examine
Examination of idiopathic skin calcification
Histopathology:
Massive calcification
There is a large amount of calcium in the subcutaneous tissue, and there is a foreign body reaction around it. In some cases, there is calcium deposition in the epidermis, and calcium can be discharged from the ulcer or through the epidermis.
2. Subcutaneous calcified nodules
Calcified substances are mainly located in the uppermost layer of the dermis, mainly dense calcified spheres, and some are one or several large homogenized calcified masses. The calcified spheres and clumps are coupled with intact nuclei, large Macrophages and foreign body giant cells can be seen around the mass, and the epidermis is thickened, and calcium particles are visible in the epidermis, suggesting that the epidermis is excreted.
Diagnosis
Diagnosis and diagnosis of idiopathic skin calcification
According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed.
