myelomonocytic leukemia
Introduction
Introduction to myelomonocytic leukemia Myelomonocyticleukemia (AMMOL) accounts for 25% of all non-lymphocytic leukemia cases. Specific skin lesions are rare and only a few have been reported. basic knowledge The proportion of illness: 0.001% Susceptible people: no specific population Mode of infection: non-infectious Complications: anemia, bacterial infection, splenomegaly
Cause
Myeloid monocytic leukemia
Causes:
The cause is still unclear.
Pathogenesis
The pathogenesis is still unclear.
Prevention
Myeloid monocytic leukemia prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Myeloid monocytic leukemia complications Complications, anemia, bacterial infection, splenomegaly
1. Anemia: manifested as fatigue, dizziness, paleness or shortness of breath after activity.
2, repeated infection and not easy to cure: mainly due to the lack of normal white blood cells, especially neutrophils.
3, bleeding tendency: easy bleeding, bleeding, bleeding gums, stool bleeding and irregular menstrual bleeding, due to thrombocytopenia.
4, splenomegaly, unexplained weight loss and night sweats.
Symptom
Myeloid monocytic leukemia symptoms common symptoms gingival bleeding nodules papules skin blister or bullous damage
Most patients have multiple red or purple-red asymptomatic papules, nodules or plaques on the head, trunk or limbs, and 18% of patients have gingival involvement. Even early manifestations of bullae, erythroderma or clinical benign Atypical skin lesions of appearance, there are also reports of chickenpox pimples lesions similar to chickenpox.
Examine
Examination of myelomonocytic leukemia
Histopathology: Atypical mononuclear cells are densely infiltrated in the dermis and subcutaneous tissue. The infiltrating is an obvious non-invasive zone separating the epidermis from the infiltration. Occasionally, the epidermal focal involvement is infiltrated by pleomorphic monocytes and The myeloid cells are mixed to form immature monocytes with irregular shape nuclei, mature monocytes, myeloblasts, occasionally eosinophils, mitotic figures, and tumor cells arranged in a band or cord Dispersed between the bundles of collagen fibers, in addition, infiltration affects and destroys blood vessels and skin attachments as a feature of AMMOL.
Histochemistry and immunohistochemistry: Most infiltrating leukemia cells were strongly positive for lysozyme staining, tumor cells were usually negative for chloroacetate staining, and immunohistochemistry showed that tumor cells mainly expressed macrophages with antigen [Leu22 ( CD43), Leu-M1 (CDl5), KP1 (CD68), HAM56 and MAC387], in addition, frozen sections can be shown to be positive for monocyte and granulocyte markers Leu-M5 (CD11c) and My7 (CDl3).
Diagnosis
Diagnosis and diagnosis of myelomonocytic leukemia
According to the clinical manifestations, the characteristics of skin lesions, histopathology, histochemistry and immunohistochemistry can be diagnosed.
