Vulvar granular myoblastoma
Introduction
Introduction to vulvar granular myogen cell tumor Vulvar granulosa cell tumor is a slow-growing benign tumor, which may be derived from a benign tumor of the nerve tissue. It is a rare tumor that can invade the tongue, skin and other parts including the upper respiratory tract, digestive tract and skeletal muscle. Occasionally, in the clitoris. basic knowledge The proportion of illness: 0.002% Susceptible people: women Mode of infection: non-infectious Complications: vulvar granular myogen cell tumor
Cause
The cause of vulvar granulocyte myopathy
(1) Causes of the disease
Electron microscopy has confirmed that tumor cells are derived from the deformation of nerve sheath cells. There have been many theories about its tissue formation, which was previously thought to have been degenerated by mature striated muscles, and then considered to be from immature striated muscles, and later Some scholars believe that it is from tissue cells or fibroblasts.
(two) pathogenesis
The tumor is mostly located in the labia majora, and the growth is slow. The part is a nodular bulge. It is mostly a single mass with a diameter of 0.5~3cm. It generally has a wide base, the texture is tough, the cut surface has no capsule, the boundary is clear, the texture is uniform, and the cut surface is Light yellow or grayish yellow, shiny.
Microscopic examination showed that the tumor cells were aggregated into thick cords or nests, separated by fine fibers, large cells, polygonal, unclear borders, abundant cytoplasm, containing distinct fine red particles, large or small, centrally located. The nucleolus is clear, and the cytoplasmic granules are not stained by mucus or glycogen, but the Sudan black B is positive. The PAS staining is still positive after enzymatic digestion, indicating that it is likely to be a glycoprotein with a lipid. A little bit of the tissue source theory that supports its neurogenicity.
Prevention
Vulvar granular myogenoma prevention
1, regular physical examination: to achieve early detection, early diagnosis, early treatment.
2, good follow-up: in order to prevent malignant transformation should be followed up after surgical resection.
3, enhance physical fitness, improve their own immunity: pay attention to work and rest, participate in physical exercise, eat more fresh fruits and vegetables rich in vitamins.
Complication
Vulvar granular myogenoma complications Complications vulvar granular myogenoma
Frequent concurrent respiratory granulocytic myblastoma. Because tumor cells can invade the upper respiratory tract and the digestive tract system, the respiratory tract is accompanied by granulocyte myoblastoma. Generally no obvious symptoms, when the tumor becomes larger, it can be expressed as a foreign body sensation in the upper respiratory tract, often with symptoms such as salivation and nasal congestion.
Symptom
Vulvar granular myogenoma symptoms Common symptoms Slow growth vulvar swelling multiple nodules
Generally no specific symptoms, sometimes the patient accidentally found a mass in the vulva, slow growth, no tenderness, tumors growing in the genital area mostly in the deep tissue of the labia majora.
Gynecological examination revealed that the mass of the genital mass was moderate, often single, sometimes multiple, without tenderness.
The texture is tough, the small mass less than 1cm in diameter, occasionally multiple nodules, the surface of the skin sometimes has hypopigmentation, can invade the vulva and the body elsewhere.
Examine
Examination of vulvar granular myogenoma
First, vaginal secretion examination:
Observe the color and traits of vaginal secretions. Vaginal secretions are liquids secreted by the female reproductive system, also known as leucorrhea. Examination can even find that the white blood cell coefficient rises.
Second, tumor marker inspection:
Tumor Marker is a chemical substance that reflects the presence of a tumor.
(1) Classification
1) Tumor tissue production, including: differentiation antigen; embryonic antigen (AFP, CEA); isoenzyme (NSE); hormone (HCG); tissue-specific antigen (PSA, free
PSA): mucin, glycoprotein, glycolipid (CA125); oncogenes and their products; polyamines.
2) The tumor is produced by interaction with the host, including: serum ferritin; immune complex; acute phase protein; isoenzyme; interleukin receptor; tumor necrosis factor.
Third, histopathological examination:
Microscopically, the tumor cells are gathered into a thick cord or nest, which is separated by fine fibers. The cells are large, polygonal, unclear, and cytoplasm rich. They contain obvious fine red particles, and the nucleus is large or small. The nucleolus is clear.
The special staining of cytoplasmic granules indicates that it is not mucus or glycogen, but Sudan black B is positive. PAS staining is still positive after enzymatic digestion, indicating that it is likely to be glycoprotein with lipids, which supports its neural source. Sexual organization source theory.
Diagnosis
Diagnosis and differentiation of vulvar granular myogen cell tumor
diagnosis
According to the medical history, characteristics and tissue biopsy can be diagnosed, the individual is generally benign, and multiple should be vigilant.
Differential diagnosis
1. Vulvar leiomyomas The tumor is hard and has a clear boundary. Pathological examination can confirm the diagnosis.
2. Vulvar fibroids This tumor has an envelope with clear boundaries, often with pedicles, and a large number of fibroblasts under the microscope.
3. The epidermal cyst has a smooth wall and is lined with a stratified squamous epithelium. The superficial layer faces the cavity, and the capsule is grayish white bean residue.
4. Vulvar malignant tumors such as vulvar leiomyosarcoma, vulvar fibrosarcoma, etc., malignant tumors grow faster, often accompanied by pain, pathological examination can confirm the diagnosis.
