scrotal inflammatory carcinoma
Introduction
Introduction to scrotal inflammatory cancer Scrotal inflammatory cancer, also known as scrotal Paget's disease, is an uncommon malignant tumor that is easily misdiagnosed as eczema, dermatitis or femoral hernia. It usually develops after 50 to 60 years of age. The progress is slow, the disease course lasts for several years to several decades, the degree of malignancy is lower than that of squamous cell carcinoma, and the prognosis is relatively better. basic knowledge Sickness ratio: 0.0001% Susceptible people: generally more than 50 to 60 years old Mode of infection: non-infectious Complications: rectal cancer prostate cancer
Cause
Sinus inflammatory cancer
(1) Causes of the disease
The tissue occurrence of extramammary Paget's disease is still unclear. Histochemical and immunohistochemical studies have found that the tissue of this disease may originate from the germplasm of pluripotent primary epithelium. Some people think that extramammary Paget's disease may have the following sources:
1 Most cases are from the epidermis itself, possibly the original pluripotent stem cells in the basal layer of the epidermis;
2 cases were from apocrine gland tumors;
3 from the epidermis sweat duct;
4 very few cases are from adjacent organ tumors.
(two) pathogenesis
The scrotum Paget disease belongs to the range of Paget disease of the extramammary skin. The pathological histology is based on the diagnosis of Paget cell nest. The Paget cells are round large cells, the cytoplasm is lightly stained, the nucleus is large and irregular, and there is no cell bridge. Containing multiple nucleoli or giant nucleoli, the nucleus often has filamentous division, and the cell clusters are nested, cord-like or island-like. The paget cells in the late stage of the disease increase, but they still do not enter the dermis. The Paget cells under the epidermis often consist of the base. The cell layer is separated from the dermis, and there may be inflammatory infiltration in the dermis. Sometimes the paget cells in the tumor appear as ring-shaped ring or adenoid structure, which often indicates poor tumor differentiation and increased risk of metastasis and infiltration.
Scrotal inflammatory cancer can be accompanied by local apocrine adenocarcinoma. It should be noted whether the inflammatory cancer spreads down to the adenoid carcinoma formed by the sweat gland duct. The original sweat gland cancer is not found in Paget cells, and the scrotum Queyrat erythema is the epidermis scale. Cellular carcinoma is also more easily histologically distinguished from Paget's disease.
Scrotal inflammatory cancer metastasized later, the main metastasis is inguinal lymph nodes, and distant metastasis occurs less.
Prevention
Scrotal inflammatory cancer prevention
Scrotal inflammatory cancer is a rare malignant tumor that is easily misdiagnosed as eczema, dermatitis or femoral hernia. If you have symptoms related to eczema, dermatitis or femoral hernia, you should go to the hospital for treatment in time to avoid delays.
Complication
Scrotal inflammatory cancer complications Complications Rectal cancer prostate cancer
About 35% of patients with extramammary Paget's disease have a subsidiary organ cancer, and 27% of patients have other parts or visceral cancers, such as rectal cancer and prostate cancer.
Symptom
Scrotal inflammatory cancer symptoms Common symptoms Skin itching Inguinal lymphadena papular erythema rash Eczema scarring
1. Local skin itching, erosion, exudation, crusting, there is still erosion and exudation after dislocation, and the lesion area gradually expands.
2. The skin lesions are all erythematous lesions, micro-longed to normal skin, the boundary is clear, but irregular as map-like, the surface of the lesion is rough, visible scarring, erosion or exudate, a few see papules, pigmentation, lesions The perimeter is bordered by normal skin.
3. Inguinal lymphadenopathy, mostly inflammatory, biopsy if necessary to rule out tumor metastasis.
Examine
Scrotal inflammatory cancer examination
Pathological examination: Paget cells were found to be the basis for diagnosis in the basal layer of the epidermis or in the lower part of the spinous layer.
Diagnosis
Diagnosis and differentiation of scrotal inflammatory cancer
diagnosis
According to the scrotal skin lesions and biopsy diagnosis is not difficult, for repeated episodes of scrotal eczema, long-term treatment of skin lesions, tissue biopsy should be organized as soon as possible.
Differential diagnosis
1. Scrotal skin cancer (squamous cell carcinoma) Has a long history of chemical industry, the tumor is single or multiple sacral or flat bulge, the inguinal can touch the enlarged lymph nodes, biopsy can be clearly diagnosed.
2. The incidence of scrotal eczema may be related to allergic factors, the patient's genital itching, soft sputum on the surface of the scrotum, repeated skin thickening, rough mossy, anti-allergic treatment, can occur at any age.
