basophilia
Introduction
Introduction to basophilia The basophils of normal adult peripheral blood account for 0% to 1% of the white blood cell differential count, and the absolute value is (0.02 to 0.05) × 109 / L. Such as the classification count > 2% (at least 200 white blood cells counted) or the absolute value > 0.15 × 109 / L (calculated by white blood cell count and classification) or > 0.1 × 109 / L (calculated by direct counting), known as basophilic Basophilia. basic knowledge The proportion of illness: 0.05% - 0.08% Susceptible people: no special people Mode of infection: non-infectious Complications: acute agranulocytosis
Cause
Causes of basophilia
Myeloproliferative diseases (20%):
Polycythemia vera, essential thrombocythemia, myelofibrosis, chronic myeloid leukemia, especially during accelerated and blast phase, basophils are significantly increased, and basophilic basophils are also present in basophilic leukemia The number of cells is increased. Some acute myeloid leukemias are particularly associated with chromosomal translocations such as t(3;6) or t(6;9), and may also have basophilia.
Metabolic and endocrine disorders (25%):
Tuberculosis (especially disseminated non-reactive tuberculosis), chickenpox, hookworm and other infections. Lead, mercury, strontium, zinc, drugs (especially all-trans retinoic acid), allergic to certain foods after injection of allogeneic proteins. Mucinous edema, diabetes, etc.
Other (15%):
Mastococcal disease, splenectomy, malignant tumor, Hodgkin's disease, hemolytic anemia, ulcerative colitis, kidney disease, irradiation, juvenile rheumatoid arthritis, early menstruation, after recombinant IL-3 injection.
Prevention
Basophilic prevention
1, go to bed early and get up early, exercise the body. Insufficient sleep can reduce the body's immune function, and it is also easy to stimulate the fire, causing external injuries.
2. Keep your mind calm. Avoid anger in the spring, do not be too impatient, always keep your peace of mind.
3. Quit smoking, drink less and drink coffee. Smoking is the most vulnerable to damage to the respiratory surface barrier and induces disease onset. Tobacco, alcohol and coffee all stimulate nervous excitement. Some people want to "eliminate tension and fatigue", but actually weaken the body's disease resistance.
4, actively participate in physical examination, found that the disease is treated in time.
5, diet should be light and nutritious and iron, eat less greasy frying and spicy food.
Complication
Basophilic complications Complications acute agranulocytosis
No other complications.
Symptom
Symptoms of basophilia Common symptoms Systemic diffuse flushing wheezing tachycardia shock blood pressure drop
Because basophils are rich in histamine, the increase can cause hyperhistamine, causing high histamine syndrome, showing fever, systemic flushing, tachycardia, asthma, blood pressure, even shock, ulcer disease and Bleeding, etc., this situation can be seen in the treatment of acute promyelocytic leukemia with all-trans retinoic acid. As one of its treatment-related syndromes, it usually appears in the treatment for 2 to 4 weeks, and basophils increase with the increase of white blood cell count. , lwakm et al found that patients with acute promyelocytic leukemia treated with all-trans retinoic acid had basophilia, and at the peak of basophils, leukocyte retinoic acid receptor alpha rearrangement was significantly reduced, indicating The basophils are not derived from leukemia cell clones, but have increased reactivity. In addition, basophils contain heparin, which may cause bleeding, and the above is unique to basophilic granulocytes.
Examine
Examination of basophilia
Peripheral blood cells can be normal or increased, basophil cell elevation classification > 2%, absolute value > 0.15 × 10 9 / L, hemoglobin, red blood cells, platelets vary according to different primary diseases.
Diagnosis
Diagnosis and identification of basophilia
According to the increase of peripheral blood basophils, the disease can be diagnosed.
