breast cancer sarcoma
Introduction
Introduction to breast cancer sarcoma Carcinosarcomaofbreast refers to a tumor co-occurring in the ipsilateral breast tissue and sarcoma, which is composed of malignant mesodermal tissue and malignant epithelial tissue. basic knowledge The proportion of illness: 0.001% Susceptible people: women Mode of infection: non-infectious Complications: nipple retraction
Cause
Causes of breast cancer sarcoma
Cause:
The cause is still unknown, and the source of the tissue is different. The tumor may be caused by malignant transformation of the glandular epithelium on the basis of phyllodes cystosarcoma; or it may be based on intraductal fibroadenomas, epithelial and interstitial components. At the same time, it can be malignant; it can also occur directly from the mammary gland, that is, from the same origin of stem cells, burdock, Fuxilin reported 7 cases of breast cancer sarcoma, 6 cases originated from stem cells.
Pathogenesis:
1. Pathological morphology: The volume of breast sarcoma is larger, showing spheroidal or lobular cysts in the cysts with surrounding tissues. The cut surface is uniform, gray-white translucent, myxoma-like or solid, mixed with myeloid, and sarcoma under the microscope. Ingredients and epithelial cancer components are inlaid and mixed, there is no migration between the two, epithelial cancer components are more common in squamous cell carcinoma, sarcoma components are fibrosarcoma, osteosarcoma, chondrosarcoma, rhabdomyosarcoma, etc., sarcoma Cancer cells often infiltrate into the connective tissue interstitial, sometimes visible fibrous tissue separation, cancer cells do not produce reticular fibers, cancer cells nest often surrounded by basement membrane, sarcoma produces reticular fibers, around the sarcoma No basement membrane.
2. Metastatic route: The metastasis of cancerous tumors is mainly lymphatic metastasis. The sarcoma is mainly caused by blood circulation, and both of them can metastasize. Generally, there are more opportunities for metastasis.
Prevention
Breast cancer sarcoma prevention
Breast cancer sarcoma is rare, and the cause is not completely clear. Patients often find a lump in the breast to visit the hospital. Therefore, it is recommended to self-examine the breast, master the correct self-test method, and develop a monthly self-examination of the breast. At the same time actively participate in breast cancer screening to prevent problems before they occur.
The breast self-examination method stands or sits in front of the mirror, and carefully observes the breasts on both sides of the breast, including the size, shape, contour, skin and color of the breast, whether the nipple is raised, retracted, or discharged. When palpation, the fingers stretched out and close together. Use your fingers to touch the breast on the ventral side. Check the right side with your left hand and the left side with your right hand. You can touch it clockwise or counterclockwise. Do not miss the nipple, areola and armpits.
Complication
Breast cancer sarcoma complications Complications nipple retraction
Lactation disorders, nipple retraction.
Symptom
Symptoms of breast cancer sarcoma Common symptoms Breast cancer distant metastasis Mammary gland degeneration Lymph node enlargement Nodular nipple retraction
Single or multiple round nodules or masses in the breast, the site of the disease is no special, the longest diameter is reported to be 4 ~ 13cm (median 7.5cm), hard, border is not clear, ipsilateral axillary lymph nodes, The mass can be promoted in the early stage. When it adheres to the fascia of the skin and pectoralis major, the activity is poor, or even completely fixed. The growth rate of the sarcoma is faster. When the tumor invades the skin, it has an "orange peel" change, which can be inside the nipple. Invagination of axillary lymph nodes and hematogenous metastasis.
Examine
Breast cancer sarcoma examination
Fine needle aspiration cytology or tissue biopsy is the main basis for the diagnosis of this disease. See the combination of cancer cells and sarcoma components, which is a characteristic of this disease.
X-ray examination of molybdenum target showed that most of the masses had smooth edges, a few of the tumors had irregular or sharp-pointed edges, uneven density, calcification, structural disorder around the lesion, and thickening of the affected blood vessels, similar to breast cancer. Imaging diagnosis is difficult.
Diagnosis
Diagnosis and diagnosis of breast cancer sarcoma
The diagnosis of breast cancer sarcoma is often difficult before the histological basis. The diagnosis based on clinical manifestations is often misdiagnosed as breast cancer, so the final diagnosis must rely on histological diagnosis.
Should be differentiated from breast cancer, the latter growth rate is relatively slow, the tumor is small, early skin and axillary lymph node invasion, fine needle aspiration cytology and pathological biopsy is the most reliable diagnostic tool, in addition to the need for breast fiber Identification of sarcoma.
