epidermolytic acanthoma
Introduction
Introduction of epidermolytic acanthoma Epidermolyticacanthoma This disease was first reported by Shapiro and Baraf in 1970 and can be divided into solitary and disseminated. basic knowledge The proportion of illness: 0.001% Susceptible people: no specific people Mode of infection: non-infectious Complications: pruritus
Cause
Epidermal aplastic acanthoma
(1) Causes of the disease
The cause is still unknown.
(two) pathogenesis
Epidermal release can explain the enhanced metabolic activity of keratinocytes or dysplastic tumor cells, and no HPV infection was detected by PCR.
Prevention
Epidermolytic acanthoma prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Epidermal lysis acanthoma complications Complications pruritus
No special complications.
Symptom
Epidermolytic acanthoma symptoms Common symptoms Weak papule itching
It can be divided into single-onset and disseminated epidermal apoptotic acanthoma. Solitary epidermolytic acanthoma has no clinically characteristic morphology and location, usually papilloma lesions less than 1 cm in diameter.
Dissemimated epidermolytic acanthoma (dissemimated epidermolytic acanthoma) is mostly scattered in flat pale brown papules, 2 to 6 mm in diameter, similar to seborrheic keratosis, occurring in the upper part of the trunk, especially the back.
Examine
Examination of epidermal loose acanthoma
Histopathology: In addition to hyperkeratosis and papilloma, in the entire germinal layer excluding the basal layer, significant epidermal hyperkeratosis, ie, granular degeneration, intraepithelial and intercellular edema, and clear keratin particles were observed. Larger than normal, vacuolar degeneration is obvious.
Diagnosis
Diagnosis and differentiation of epidermal loose acanthoma
According to the clinical manifestations, the pathological features of the lesions can be diagnosed.
Excessive keratinization of epidermis, can be seen in many skin diseases, including bullous ichthyosis erythroderma, high ichthyosis, palmoplantar keratosis, unilateral epidermal sputum, epidermal loosening mucosal leukoplakia, unbound Clinical manifestations are indistinguishable from epidermolytic acanthoma. In addition, the identification of this disease and sputum is also necessary. Endogenous sputum (inlaid sputum) can be typical perinuclear vacuoles and many transparent keratinous granules, but its The eosinophilic keratin particles are more than the epidermis keratosis, and the dermal papillary vessels are dilated and papilloma is obvious.
