granuloma of the face
Introduction
Introduction to facial granuloma Facial granuloma was first reported by Nigley in 1945, also known as eosinophilic facial granuloma. Direct immunofluorescence examination of lesions showed mainly IgG deposition in the blood vessels or around the blood vessels, suggesting that the disease may be immune complex-mediated chronic leukocyte fragmentation vasculitis. The disease should be differentiated from persistent inflammatory erythema. There is no infiltration under the epidermis. The eosinophils in the infiltration are significantly increased, while the persistent inflammatory erythema infiltration has almost no eosinophils and no infiltration zone. . Low-dose dapsone is effective, and can also be treated with puvA or intralesional corticosteroids. basic knowledge The proportion of illness: 0.025% Susceptible people: no special people Mode of infection: non-infectious Complications: swelling
Cause
Facial granulomatosis
(1) Causes of the disease
Direct immunofluorescence examination of lesions showed mainly IgG deposition in the blood vessels or around the blood vessels, suggesting that the disease may be immune complex-mediated chronic leukocyte fragmentation vasculitis.
(two) pathogenesis
The pathogenesis is still unclear and may be immune complex-mediated chronic leukocyte fragmentation vasculitis.
Prevention
Facial granuloma prevention
Early detection and early diagnosis and early treatment.
Complication
Facial granulomatous complications Complications swelling
The disease may be caused by a rubbery swelling of the skin due to occlusion of the lymphatic vessels, and the patient may be damaged by scratching, so that the skin may be caused by bacterial infection or fungal infection, usually secondary to low constitution or long-term use. Immunosuppressive agents and patients with fungal infections such as onychomycosis, such as concurrent bacterial infections, may have symptoms such as fever, swelling of the skin, ulceration, and purulent secretion. Severe cases can lead to sepsis, which should be brought to the attention of clinicians.
Symptom
Facial granulomatous symptoms Common symptoms Granuloma generalized red plaque chronic ulcer shaped reticulocyte
The lesion is one or more reddish-brown or purple-red plaques. The diameter of the plaque can reach several centimeters. Except for the expansion of the hair follicle, the surface of the lesion is normal, which occurs in the nose, sputum, forehead, and a few can occur in the face. Other parts such as the forearm, neck, chest, do not invade the internal organs, can relieve themselves.
Examine
Examination of facial granuloma
Histopathological examination: visible dense polymorphic infiltration, mainly located in the upper part of the dermis, in some parts can also extend deep into the dermis, even subcutaneous tissue, infiltration does not invade the epidermis or fur gland attachment, and is bounded by the narrow normal collagen boundary band, will The epidermis and infiltration are separate from the histopathological features of the disease. Most of the pleomorphic infiltration consists of neutrophils and eosinophils. Frequently, some neutrophil nucleus fragments, forming nuclear dust, and many telangiectasia. Strong eosinophilic substances appear in and around the vessel wall, and a small number of red blood cells are seen.
Diagnosis
Diagnosis and diagnosis of facial granuloma
The disease should be differentiated from persistent inflammatory erythema. There is no infiltration under the epidermis. The eosinophils in the infiltration are significantly increased, while the persistent inflammatory erythema infiltration has almost no eosinophils and no infiltration zone. .
