Diffuse palmoplantar keratosis
Introduction
Introduction to diffuse palmoplantar keratosis Diffusepalmoplantarkeratodermia is also known as hereditary palmoplantarhypereratosis, palmoplantar disease, palmoplantar keratinoma, Thost-Unna syndrome. More from infancy. The lighter only has rough skin in the palm of the hand. In severe cases, diffuse plaques appear in the palmar palpebral, the marginal keratin is thickened, the performance is smooth, the color yellow is like a sputum, or it is thickened in a scorpion shape, often causing cleft palate due to the disappearance of elasticity, causing pain. basic knowledge The proportion of illness: 0.001% Susceptible people: no special people Mode of infection: non-infectious Complications: swelling
Cause
Diffuse palmoplantar keratosis
(1) Causes of the disease
It is autosomal dominant and can occur in all races. The incidence of both sexes is roughly equal. The incidence rate is 1:40,000 in Northern Ireland.
(two) pathogenesis
The pathogenesis is still unclear, autosomal dominant inheritance, and may be autosomal dominant inheritance.
Prevention
Diffuse palmoplantar keratosis prevention
The disease belongs to autosomal dominant inheritance. All races can occur, the incidence of both sexes is roughly equal, and the incidence is statistically high in Northern Ireland at 1:40. Have family. Therefore, it is impossible to prevent the cause of this disease, and chromosome examination can be performed before pregnancy. For those with serious chromosomal abnormalities, marriage should be avoided. At the same time, close relatives should be avoided, and the prevalence of the disease can be reduced.
Complication
Diffuse palmoplantar keratosis complications Complications swelling
Skin integrity is destroyed due to skin rupture, so skin bacterial infections or fungal infections can be induced by scratching, usually secondary to low body weight, or long-term use of immunosuppressive agents and fungal infections such as onychomycosis, such as concurrent Bacterial infections may have symptoms such as fever, swelling of the skin, ulceration, and purulent secretion. Severe cases can lead to sepsis, which should be brought to the attention of clinicians.
Symptom
Diffuse palmoplantar keratosis symptoms Common symptoms Hand, foot, splitting, keratin, thickening, rough skin, generalized red plaque
Mostly from infancy, the lighter only has rough skin in the palm of the hand. In severe cases, there is diffuse plaque in the palm of the hand. The marginal keratin is thickened, the performance is smooth, the color is similar to the sputum, or it is thickened in the shape of the sputum. Cleft palate, causing pain, causing difficulty in hand and foot activities can be limited to the palmar palpebral, occasionally the back of the hand, the back of the foot, the fingers, the toes, the elbows, the knees, the extension of the forearm, the anterior and posterior iliac crests can also be involved, symmetrically distributed, With sweating, thickened deck, turbidity, some patients may have congenital ichthyosis or other congenital anomalies, and the lesions last for a lifetime.
Examine
Diffuse palmoplantar keratosis examination
Clinical skin examination: the skin of the palmar sputum is rough, and the diffuse plaque appears in the palm of the hand. The keratin of the edge is thickened, the performance is smooth, the color is similar to the sputum, or it is thickened in the shape of the sputum, often causing cleft palate due to the disappearance of elasticity, causing pain. Difficulties caused by hand and foot activities can be limited to the palmar palpebral, occasionally the back of the hand, the back of the foot, the fingers, the toes, the elbows, the knees, the extension of the forearms, the anterior and temporal iliac crests can also be involved, symmetrically distributed.
Histopathology: thickening of the stratum corneum, poor keratinization, thickening of the granules and acanthosis, mild infiltration of inflammatory cells in the superficial dermis. The sweat glands and sweat tubes occasionally shrink.
Diagnosis
Diagnosis and differentiation of diffuse palmoplantar keratosis
diagnosis
According to the clinical manifestations of histopathology and family history, the diagnosis is not difficult.
Differential diagnosis
Need to be differentiated from the following diseases:
1. Hyperkeratotic hand, foot and ankle, this disease belongs to the fungal infection of the skin, often accompanied by obvious desquamation and itching of the skin. Fungal hyphae and spores can be found on the microscopic examination of skin lesions.
2. Chest palm eczema, the disease is a skin allergic disease, often has a history of acute attacks, other parts may also have eczema skin lesions, may be accompanied by yellow secretions, the main itch.
