Papular purpuric glove and sock syndrome
Introduction
Introduction to Pimple Purpura Gloves and Socks-like Syndrome Pimples purpura gloves and sock-like syndrome were first reported by Harmas in 1990. They are characterized by mild edema of the hands and feet and erythema, accompanied by purpura. The lesions can be extended to the wrist and ankle, in the form of gloves and socks. Distribution, hence the name. This disease occurs in young people, before the rash can have fever, mild and severe systemic symptoms, after 2 to 4 days after the rash, manifested as hands, feet skin flushing, mild edema and flat papules, skin lesions can be extended to Wrists and ankles are distributed in gloves and socks. A small number of patients have rashes, mild itching or pain in the elbows, knees, buttocks and inner thighs. basic knowledge The proportion of illness: 0.001% Susceptible people: no specific population Mode of infection: non-infectious Complications: gastrointestinal bleeding
Cause
The cause of papules, purpura gloves and sock-like syndrome
(1) Causes of the disease
Considered as a parvovirus infection.
(two) pathogenesis
Harmas et al. used polymerase chain reaction (PCR) to detect IgM antibodies positive for parvovirus B19 (parvirus B19; PVB19). PVB19 was also positive for IgM seroconversion, while other bacteria and viruses were negative.
Prevention
Pimple purpura gloves and sock-like syndrome prevention
The disease is a viral infection, so the prevention program should be directed to the virus. At present, there is no vaccine interview for this disease, so the prevention measures are mainly to improve the body function, increase the resistance, reduce or avoid the occurrence of this disease. Usually you can eat more foods with high vitamin C content, such as kiwi, lemon, thorn pear fruit, etc., vitamin C has a strong reduction, can enhance the resistance to avoid virus invasion. Early detection, early treatment.
Complication
Pimples purpura gloves and complications of sock-like syndrome Complications, gastrointestinal bleeding
Because the disease is related to viral infection, and coagulation dysfunction and other causes of skin purpura, so the disease can cause bleeding in other parts, usually gastrointestinal bleeding, the amount is not large, often accompanied by melena and abdominal pain. This disease can cause the hardening of the small arteries of the kidney into the ball, so the kidney function can be inhibited, so it should be noted to monitor the renal function and talk about routine.
Symptom
Pimples purpura gloves and socks-like syndrome symptoms Common symptoms Pimples itching erythematous rash lymph nodes swollen fever edema facial flushing
This disease occurs in young people. Before the rash, there may be fever, systemic symptoms ranging from mild to severe. After 2 to 4 days, the rash appears as hands, foot skin flushing, mild edema and flat papules. The lesion can be extended to Wrists and ankles are distributed in gloves and socks. A small number of patients may also have rashes on the sides of the elbows, knees, buttocks and thighs, mild itching or pain. In addition, the oral mucosa may have erythema, purpura, buccal mucosal erosion, pharyngitis. , cheilitis and angular keratitis, lymph nodes, the course of disease for 1 to 2 weeks, and then the skin lesions and desquamation.
Examine
Examination of papular purplish gloves and sock-like syndrome
Leukocytes can be reduced, neutrophils and monocytes are increased, and anti-PVBl9 antibodies are positive.
Pathological changes: lymphocytic infiltration around the dermal papilla layer, and hemorrhagic dermatitis-like changes in the superficial dermis.
Diagnosis
Diagnostic identification of papules, purpura gloves and sock-like syndrome
According to the fever, the hands and feet of the wrist are covered with gloves and socks-like redness, purpura, papular rash, accompanied by oral erythema erythema, erosion and sputum, PVB19 antibody positive, can be diagnosed.
