Mycobacterium scrofula infection
Introduction
Introduction to Mycobacterium tuberculosis infection Mycobacterium scrofulaceum is widely distributed in nature. Tissue culture can produce yellow pigment in the dark. Colonies are produced on Roche medium at 30 ° C and 37 ° C for 2 to 3 weeks, and no growth occurs below 25 ° C. . If cultured at 37 ° C for 3 days and then cultured at 25 ° C can grow rapidly, the pathogenesis is still not clear. The clinical manifestations are granulomatous nodules from 10 days to several months after trauma, and may also be erysipelas-like appearance. The damage is usually single, no systemic symptoms, acid-fast bacilli culture and strain identification can be diagnosed. Can heal itself. Antibiotics and vaccine treatment can speed up recovery. basic knowledge Sickness ratio: 0.0001% Susceptible people: no special people Mode of infection: non-infectious Complications: erysipelas
Cause
Causes of mycobacterial infection
(1) Causes of the disease
Mycobacterium scrofulaceum, a pathogen of mycobacterium scrofulaceum infection, is widely distributed in nature, in warm and humid, low pH, low dissolved oxygen, high soluble zinc and humic acid soil and water. In the environment, tissue culture can produce yellow pigment in the dark. Colonies are produced on Roche medium at 30 ° C and 37 ° C for 2 to 3 weeks, and do not grow below 25 ° C. If cultured at 37 ° C for 3 days, then The culture can be rapidly grown at 25 °C, and the formed colonies are smooth and moist with a yellow film. The color of the cells is unchanged, the bacteria are larger than the tuberculosis bacteria, the acid resistance is also strong, the enzyme reaction is strongly positive, the niacin test is negative, and the sulfonamide is negative. , erythromycin and other sensitive, resistant to isoniazid and PAS.
(two) pathogenesis
The pathogenesis is still not clear.
Prevention
Mycobacterium infection prevention
There is no effective preventive measure for this disease, and early treatment should be detected early.
Complication
Mycobacterium infection Complications
The nodule lesion is more rash, the papule damage is large and deep, and it penetrates deep into the deep dermis, and the heavy one can reach the subcutaneous tissue. The surface is semi-circular and smoother. The surface of the inflammatory nodules is red, painful and angular pain, and the diameter is 0.5~5cm. In the late stage, there are often ruptures, such as late syphilis nodular lesions, and skin tuberculous nodules are debilitating. The histopathological changes of the nodules are deeper in the deep dermis and can invade the subcutaneous fat layer, so it can be associated with changes in lipid membranes and blood vessels.
Symptom
Mycobacterium tuberculosis infection symptoms common symptoms granulomatous nodule erysipelas
Granuloma nodules from 10 days to several months after trauma, can also be erysipelas-like appearance, only mild pain, no other symptoms, nodules no more than a few centimeters, can form a fistula with pus overflow, can also The surface keratinization hyperplasia is sputum-like, and the scar is left after 1 year. The damage is often single, but if multiple traumas can cause multiple skin lesions, the local lymph nodes can be swollen and there is no systemic symptoms.
Examine
Examination of mycobacterial infection
The dermis and subcutaneous tissue are non-specific chronic inflammatory granuloma changes, infiltrating cells are tissue cells, fibroblasts, plasma cells, neutrophils, infiltrating the upper layer of the dermis is diffuse, in the middle and lower layers around the skin appendage Sometimes, although giant cell-like epithelioid cells are seen, there is no obvious tuberculosis structure and cheese-like changes, and acid-fast bacilli can be seen in the acid-fast staining of tissue sections.
Diagnosis
Diagnosis and identification of mycobacterial infection
diagnosis
Chronic granuloma with almost no symptoms after trauma, can be fistula or sputum, local lymphadenopathy, acid-fast bacilli culture and strain identification can be diagnosed.
Differential diagnosis
It should be differentiated from sporotrichosis, verrucous skin tuberculosis, foreign body granuloma.
