ovarian amphoblastoma
Introduction
Introduction to ovarian neutrophiloma Gynaldroblastoma is a benign ovarian tumor that has been reported in dozens of cases at home and abroad. Although there are relatively clear diagnostic criteria for pathological morphology, the biological behavior of this tumor is not well understood because of its small number. Since the tumor is composed of a granule-bubble component and a supporting-interstitial component, the tumor cells can secrete estrogen and also secrete androgen, and thus various manifestations of endocrine changes occur clinically. basic knowledge The proportion of illness: 0.002% - 0.003% Susceptible people: women Mode of infection: non-infectious Complications: precocious puberty
Cause
Ovarian hemophiloma etiology
(1) Causes of the disease
The etiology of ovarian neutrophiloma is unclear.
(two) pathogenesis
1. The general examination is mostly unilateral, 6~20cm in diameter, mostly below 6cm, oval, with or without capsule, smooth surface, grayish-cut face, gray powder or brown, mostly solid, and more Room or cystic.
2. Under the microscope, the tumor contains supporting cells, mesenchymal cells and well-defined granular cells containing Call-Exner bodies, which are intermingled with tumors rather than independent components.
Prevention
Ovarian amphiblastoma prevention
It is very important to maintain a good attitude, to maintain a good mood, to have an optimistic, open-minded spirit, and to be confident in the fight against disease. Don't be afraid, only in this way can you mobilize your subjective initiative and improve your body's immune function.
Complication
Ovarian hereditary blastoma complications Complication precocious
Causes precocious puberty, which can cause tumor and pedicle torsion, bleeding and necrosis, which can cause urination and difficulty in defecation. Due to the oppression of ovarian tumors, mild oppression can enhance the endocrine function of the ovary, which is an increase in the secretion of estrogen and progesterone. Severe oppression can cause the ovaries to shrink and function decline. When the pedicle is reversed, it will cause severe pain in the abdomen, which is an acute abdomen of gynecology.
Symptom
Symptoms of ovarian hermablastoma Common symptoms Amenorrhea menopause, clitoris, hypertrophy, postmenopausal bleeding, menstrual volume, pelvic mass, masculinization
1. Pelvic masses of bismuth blastoma occur mostly in unilateral ovaries, with an average diameter of 6 cm or less. Through careful pelvic examination and B-ultrasound and other auxiliary examinations, most of the attachment area can be found in solid attachment lesions, but McClugage et al. One case (1996) reported a tumor weighing 1490 g and a volume of 21 cm x 14 cm x 10 cm.
2. Endocrine changes Because tumors are composed of granule-bubble components and supporting-interstitial components, tumor cells can secrete estrogen and secrete androgen, so there are many manifestations of endocrine changes in the clinic.
(1) estrogen effects: there may be more menstrual, postmenopausal bleeding and other clinical symptoms, as well as uterine enlargement, endometrial hyperplasia pathological changes.
(2) androgen effects: amenorrhea, breast atrophy, hairy, low-pitched voice, clitoris hypertrophy and other masculine symptoms, will appear in some patients.
(3) There are also male and female symptoms that are present or have symptoms.
Examine
Examination of ovarian hermablastoma
Hormone level check
Increased levels of estrogen and testosterone.
2. Histopathological examination
(1) The general inspection is mostly unilateral, with an average diameter of 6 cm or less. Oval and smooth surface. The cut surface is grayish yellow, gray powder or brown. More solid, can also have multiple rooms or cysts.
(2) Microscopic examination of granulosa cells and vesicular cells containing support cells, mesenchymal cells, and well-defined Call-Exner bodies, and intermingled with each other in tumors.
Diagnosis
Diagnosis and differentiation of ovarian hermablastoma
Diagnostic criteria
Because tumors are very rare, the clinical symptoms of endocrine disorders are more difficult to distinguish from other types of ovarian cord stromal tumors. Preoperative diagnosis is very difficult.
The main point of pathological diagnosis is that the tumor tissue must contain both interstitial cell components and granule-bubble cell components in order to be diagnosed. The granule cell components are mainly adult granulosa cell tumors, and fresh juvenile granulosa cell tumors. One case reported by McCCluggage is not only bulky, but also prominent in the tumor composition of juvenile granulosa cell tumor components, as well as heterologous intestinal epithelial glands, which have not been reported in the literature.
The presence of inhibin and MIC2 antibodies in serum may indicate the presence of adult or juvenile granulosa cell tumors, which may be useful for preoperative analysis and diagnosis.
Differential diagnosis
It should be differentiated from other types of tumors in ovarian sex cord stromal tumors.
