lymphomatoid papulosis
Introduction
Introduction to lymphomatoid papulosis Lymphomatoid papulosis is a low-grade malignant T-cell lymphoma characterized by chronic, recurrent, self-limiting papular nodular skin lesions. basic knowledge The proportion of illness: the incidence rate is about 0.004%-0.008% Susceptible people: no special people Mode of infection: non-infectious Complications: subcutaneous T-cell lymphoma
Cause
Causes of lymphomatoid papulosis
(1) Causes of the disease
The cause is not clear.
(two) pathogenesis
The pathogenesis is still unclear.
Prevention
Lymphoma-like papulosis prevention
Reducing environmental pollution, maintaining good living habits, timely treatment of certain chronic inflammatory diseases of the body, and improving the immune function of the body may not only reduce the incidence of lymphoma, but also reduce the incidence of other malignant tumors.
Complication
Lymphoma-like papillary complications Complications Subcutaneous T-cell lymphoma
It can be complicated by Mycosis fungoides (MF), formerly known as mycosis fungoides, and is a type of cutaneous T-cell lymphoma. It is the most common type of primary cutaneous T-cell lymphoma, accounting for 54% of all cutaneous lymphomas.
Symptom
Symptoms of lymphoma-like papules Common symptoms Pimples pimples pustules
Common in adults aged 20 to 40 years old, most of the typical cases, the damage and similar acute acne-like lichen-like pityriasis, the difference is greater damage, less number and more necrotic tendency, primary lesions Red papules, up to about 1cm in diameter, can progress to papular vesicular, papular pustular or hemorrhagic, surface necrosis after several days, typical damage can heal within 8 weeks, most tend to be chronic, without Treatment, new damage continues to appear, so skin lesions can exist at different times, damage to the left after the cure of acne-like, pigmentation or hypopigmentation scar, the symptoms are mild, the course of disease 3 months to 40 years, 10% to 20 % of patients with lymphoma-like papulosis can develop MF, CD30 cutaneous T-cell lymphoma or Hodgkin's disease.
Examine
Examination of lymphoma-like papulosis
1. Histopathology: histological diagnosis of the disease, the dermis is wedge-shaped, patchy or perivascular infiltration, large lesions infiltrate can occupy the entire dermis, infiltration can affect the epidermis with inflammatory cells pro-epidermal, damage progress Epidermal necrosis and erosion can occur, fibrin deposition can be seen in the dermis, and lymphocytic vasculitis can be seen. The dermal infiltrating cells are composed of lymphocytes, eosinophils and neutrophils and larger monocytes. Sexually large or small lymphoid cells account for more than 50% of infiltrating cells, and histological damage can be divided into two types, A and B.
Type A damage contains atypical large cells, cytoplasm rich and obvious eosinophilic nucleoli. If the cell contains two nuclei, it is similar to ReedSternberg cells, type B damage, atypical cells are smaller, the nucleus is smaller, staining Deep, cerebral gyrus, atypical cells similar to MF, atypical fibrosis can be seen in both types of damage.
2. Immunohistochemistry: large atypical cells, which are helper T cell phenotypes, atypical cells, especially type A cells, positive for ki-1 or CD30 staining, PCR gene cloning rearrangement seen in more than 40% of lymphoma-like papules Disease damage.
Diagnosis
Diagnosis and diagnosis of lymphomatoid papulosis
According to the clinical manifestations, the characteristics of skin lesions, histopathological features, immunohistochemical examination can be diagnosed.
