senile chorea
Introduction
Introduction to senile chorea Senile chorea (senilechorea) often occurs in the elderly over 60 years old. The lesions in the brain are very similar to those in Huntington's disease. The caudate nucleus and the nucleus of the caudate nucleus are small and small, and the cerebral cortex is not tired. The dance movement of this disease sometimes appears only in the tongue, face, and buccal muscle regions. In order to distinguish it from chronic progressive chorea, it is currently inclined to list it as an independent disease unit. basic knowledge The proportion of illness: 0.001% Susceptible people: the elderly Mode of infection: non-infectious Complications: epilepsy
Cause
Causes of senile chorea
Cause of disease:
The etiology of this disease is not clear, but it has been reported that the senile chorea is caused by vascular diseases. It is also reported that this disease is a hereditary disease that occurs in the elderly.
The pathogenesis of this disease is still not clear. It is believed that senile chorea is caused by vascular diseases. The pathological changes are very similar to those of chronic progressive chorea. The caudate nucleus and the putamen are large, and the small neurons are degenerated, but there is no cerebral cortex. Transmutation, however, in recent years, many people pointed out that chronic progressive chorea can also occur in the elderly, based on the report of a part of sporadic cases in addition to family history.
Prevention
Senile chorea prevention
The pathogenesis of this disease is not clear, and may be caused by vascular diseases. It is also reported that this disease is a hereditary disease that occurs in the elderly. Pre-symptomatic genetic diagnosis has been carried out more widely in foreign countries, and detailed guidelines have been made. However, before doing this examination, the examinee must be made aware of the pros and cons of pre-symptomatic diagnosis, especially whether the psychological diagnosis can be positive. On the other hand, the experiment for pre-symptomatic diagnosis is very demanding. Pay attention to daily protection, and the elderly should try not to live alone.
Complication
Senile chorea complications Complications
The literature reports that senile chorea can be combined with other diseases, and individual patients can be complicated by epilepsy, cerebrovascular disease, hereditary ataxia and migraine. Becker, Doll, Pearson, Mackey, Bruym, etc. reported that the disease combined with progressive muscular dystrophy, polycythemia, neurofibromatosis, deformity osteitis (Paget disease) and distal (hand and foot) neurogenic muscle Shrinking and so on. Schroeder (1931) and Haberlandt (1961) reported that the disease is associated with amyotrophic lateral sclerosis.
Symptom
Symptoms of senile chorea common symptoms abnormally large dance-like movements of the ankles deformed dance-like gait limb disorders epileptic seizures
Senile chorea has a rapid onset, no family history, late onset (mostly 60 years old or older), dance-like movements are light, and the only symptom, without intelligent decline, dance-like movements sometimes only appear In the tongue, face and buccal muscle areas, it is a benign course, which can be distinguished from Huntington's disease, but sometimes it is difficult to distinguish it from sporadic Huntington's disease. It is also reported that age spots (SP) or plaques can be found in the brain tissue of patients with senile chorea. Known as neuritic plaque (NP), it is considered that senile chorea is an age-related hereditary disease.
Examine
Examination of senile chorea
Cerebrospinal fluid can be found to have decreased levels of gamma-aminobutyric acid.
1. Genetic testing is an important means of identification.
2. EEG can have diffuse abnormalities, no specificity, mainly low-wave amplitude fast-wave, especially the frontal lobe is obvious, the abnormal rate accounts for 88.9%, activity decreases or no, the amplitude decreases, and the visual evoked potential amplitude decreases, but the first The partial latency of the wave is normal.
3. Imaging examination Head CT or MRI has important clinical value for the identification of Huntington's disease.
Diagnosis
Diagnosis and diagnosis of senile chorea
diagnosis
According to the onset of senile disease, no family history, dance-like movements are the only symptoms, without intelligent decline, generally can make a diagnosis.
Differential diagnosis
It is important to note the identification of the outbreak of Huntington's disease in the elderly.
