corneal squamous cell carcinoma
Introduction
Introduction to corneal squamous cell carcinoma Corneal squamous cell carcinoma (cornealsquamous cellcarcinoma) is a malignant tumor derived from the corneal epithelium. The cause is unknown. It can be originated from a healthy corneal epithelium. It can also be a corneal epithelial carcinoma (in situ carcinoma) that breaks through the epithelial basement membrane and invades the deep cornea. To. The disease is more common in older people over the age of 50, more men than women. It occurs in the limbus of the cleft palate, which is most common in the temporal side. basic knowledge The proportion of illness: 0.005% Susceptible people: more common in the elderly over 50 years old Mode of infection: non-infectious Complications: iridocyclitis keratitis
Cause
Causes of corneal squamous cell carcinoma
Cause (50%):
May be associated with ultraviolet radiation and human papillomavirus (HPV) infection, the specific cause is unclear, it is speculated that ultraviolet radiation and other factors can cause DNA damage, when the DNA repair delay or failure, leading to somatic mutation and tumor cell development, Epithelial cancer that occurs on the surface of the eye is less malignant.
Prevention
Corneal squamous cell carcinoma prevention
1. Maintain an optimistic and happy mood. Long-term mental stress, anxiety, irritability, pessimism and other emotions will make the balance of the cerebral cortex excitatory and inhibition process imbalance, so you need to maintain a happy mood.
2, life restraint pay attention to rest, work and rest, life orderly, maintain an optimistic, positive, upward attitude towards life has a great help to prevent disease. Do the regularity of tea and rice, live daily, not overworked, open-minded, and develop good habits.
Complication
Corneal squamous cell carcinoma complications Complications iridocyclitis keratitis
Peripheral invasion can produce keratitis and iridocyclitis. Patients with keratitis often have eye pain, shame, tears and eyelids. This is caused by inflammation of the trigeminal nerve endings in the cornea, causing reflex orbital muscle contraction and tear secretion. Patients with complicated iridocyclitis may have photophobia, tearing, and painful manifestations. The pain is more obvious at night and can affect the surrounding area. When the photophobia is strong, eyelids, tearing and blinking may occur, vision loss, early vision loss is lighter, and visual acuity is aggravated in the late stage if various complications occur.
Symptom
Corneal squamous cell carcinoma common symptoms squamous cell carcinoma gray-white nodule serous purulent secretion papillary mass
It originates in the cornea, but at the same time invades the limbus and conjunctiva. The lesion is grayish white nodules at the beginning, and gradually develops into a pterygium or papillary mass in the cornea. Sometimes the tumor is a rubbery bulge, the base is wide, and the base is wide. In the blood vessels, when the tumor grows up, the surface of the tumor is uneven and cauliflower-like, and there are ulcers. The blood vessels around the tumor are dilated. When there is secondary infection, there is often a purulent discharge in the conjunctival sac.
Examine
Examination of corneal squamous cell carcinoma
1.HPV gene detection
HPV genotypes were detected in patients using monoclonal antibodies and acid hybridization techniques.
2. Pathological examination
It can be seen that the corneal epithelium abnormally proliferates, the layer becomes thicker, the squamous cells are papillary hyperplasia, the basal cells become larger, and the basal cells become larger and different in size, and the arrangement is not complete. There may be keratinization or incomplete keratinization, cell polarity disorder, and abnormality. Sexuality, visible mitotic figures, characterized by cancer cells breaking through the epithelial basement membrane to invade the corneal parenchyma.
Diagnosis
Diagnosis and diagnosis of corneal squamous cell carcinoma
Due to the barrier of the corneal anterior elastic layer, the tumor multi-directional conjunctiva and corneal surface spread, the degree of malignancy of the corneal squamous cell carcinoma is low, and it is confined to the superficial layer and the superficial layer for a long time. In a few cases, the tumor invasion Deep and Schlemm tube expansion into the eye, lymph node metastasis is rare, even if the local lymph node enlargement, mostly due to secondary infectious inflammation, only a few cases died after a few months or years of distant metastasis .
