subcorneal pustular skin disease
Introduction
Introduction to pustular dermatosis under the cornea Subcorneal pustular dermatosis (subcorneal pustulardermatosis), also known as Sneddon-Wilkison disease, is a chronic benign recurrent pustular skin disease. It is more common in middle-aged women. The pathological changes are under-pallas pustules. In 1956, Sneddon and Wilkinson et al first reported the disease. This disease is similar to the "dawn bean sore" recorded in the medical literature of the motherland. basic knowledge The proportion of illness: 0.002% Susceptible people: more common in middle-aged women Mode of infection: non-infectious Complications: pruritus, pruritus, pemphigus
Cause
Causes of pustular skin disease under the cornea
Causes:
The cause is still unclear. Some people think that it is related to infected lesions, trauma, endocrine dysfunction, etc. It is also believed that this disease may be a variation of some other skin diseases such as herpes-like impetigo, generalized pustular bacterial rash.
Pathogenesis
The pathogenesis is still unclear.
Prevention
Prevention of pustular skin disease under the cornea
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Pelvic dermatosis complications Complications pruritus pruritus pemphigus
Pemphigus vulgaris
1) Characteristics of skin lesions: loose bullae, easy to rupture, forming erosion surface and not easy to heal
2) Skin lesions: can be spread throughout the body. 60% first oral involvement
3) Nymphosis: concept and meaning, which other diseases can also be found
4) Age of occurrence: middle-aged
5) Prognosis: worst
6) Clinical examples
2. Proliferative pemphigus
1) It is the opposite sex of the vulgaris. According to Neumann type & Hallopeau type (benign proliferative pemphigus)
2) Features: -like proliferation or papillary hyperplasia
3) Location: wrinkles around the groin and around the nose and mouth
3. Deciduous pemphigus
1) Characteristics of skin lesions: loose blisters, extensive erosion, leafy scars
2) Location: can spread the whole body, less affected by the mouth
3) Prognosis: poor
4. erythematous pemphigus (Senear-Usher syn.)
1) is a deciduous type of benign
2) Characteristics of skin lesions: erythema, scarring, similar to DLE or seborrheic dermatitis
3) Parts: head, face, chest, upper back
4) Prognosis: good, can be transformed into deciduous or vulgaris
Symptom
Pelvic dermatosis symptoms under the corner layer Common symptoms Itching scaly mucosal damage blush
Occurs in middle-aged women, but there are reports of childhood morbidity. The lesions are sterile superficial pustules such as impetigo, which are arranged in a ring or a scorpion shape. They occur in the upper limbs, the groin and the armpits, and the blisters are sometimes visible. But often pustules, pustules are often oval, blister wall loose, sometimes the upper part is clear, the lower part is turbid, it is a crescent moon, there is a red halo around the early pustules, and after a few days the pustules absorb or rupture, leaving a superficial Thin sputum, scaly healing leaves brown pigmentation, no atrophy, generally no symptoms, mild pruritus, fever and other systemic symptoms, mucosal damage is rare, pus culture without bacterial growth, seizures and relief alternate, interval A few days or weeks, chronic passage, generally does not affect health.
Examine
Examination of pustular skin disease under the cornea
Histopathology: Pustular blister is located under the horny layer similar to impetigo and deciduous pemphigus, but without spine release, the blister base is composed of the uppermost layer of the granular layer and the spinous cell layer, and the blister contains a large number of neutrophils. Occasionally, eosinophils, sponge formation in the epidermis, neutrophils and some eosinophils in the dermis of the vesicles, no autoantibodies existed in direct immunofluorescence.
Diagnosis
Diagnosis and differentiation of pustular dermatosis under the cornea
According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed.
Pelvic episodes should be differentiated from impetigo, herpes-like dermatitis, deciduous pemphigus, and acute generalized impetigo.
Early lesions of the disease and impetigo may not be easily identified, but for aseptic pustules, local and systemic antibiotic treatment is ineffective, and the natural course of the disease is helpful for diagnosis, and herpes-like dermatitis is a papule blisters Sexual damage, blister is subcutaneous, severe itching, damage is mainly located in the extension of the body and the special manifestation of immunofluorescence is helpful for diagnosis. This disease sometimes needs to be differentiated from pustular psoriasis, the latter has systemic symptoms such as fever. Weakness, elevated white blood cells, the presence of spongy pustules in the epidermis and ineffectiveness of sulfone drugs help to identify.
