pseudoacanthosis nigricans
Introduction
Introduction to pseudo-black acanthosis Pseudoacanthosis Nigricans is a benign acanthosis nigricans disease that occurs more frequently in obese people. basic knowledge The proportion of illness: 0.06% Susceptible population: often occurs in obese people Mode of infection: non-infectious Complications: cerebral arteriosclerosis, diabetes
Cause
The cause of pseudo-black acanthosis
(1) Causes of the disease
It is still unclear that obesity is an important factor. Drugs such as estrogen and glucocorticosteroids can also induce this disease. Of course, a warm and humid environment can also promote this disease. Histopathological changes are no different from other types of acanthosis nigricans.
(two) pathogenesis
It is still unclear.
Prevention
Pseudo acanidosis prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Pseudo acanthosis nigricans Complications
The disease is mainly related to obesity, so patients with this disease usually have a significant increase in body weight, BMI often exceeds 25, so clinical complications are also related to obesity. Long-term hyperlipidemia can cause hardening of the arteries and increased fragility can increase the risk of cardiovascular and cerebrovascular diseases. At the same time, obese patients are often accompanied by insulin resistance, which can cause abnormal glucose tolerance and increase the risk of diabetes.
Symptom
Symptoms of pseudo-Acanthosis nigricans Common symptoms Light brown spots can have skin blemishes,...
The skin is grayish brown or light gray yellow velvety appearance, especially in the armpits, the neck side, the breasts and the groin. When the skin is rubbed, the papilloma-like disease changes clearly. In addition, the skin of the armpit is easy to let. People associate with fibrous soft tumors, and when they lose weight, the skin symptoms subsided.
Pseudo acanthosis is always associated with obesity and black hair.
Examine
Examination of pseudo-black acanthosis
Clinical skin examination: The skin has a grayish-brown or light gray-yellow velvety appearance, especially in the armpits, the cervical side, the breasts, and the groin. When the skin is rubbed, the papilloma-like disease changes clearly.
Pathological examination: single-pocket type showed thinning and flattening of the epidermis, and increased pigmentation in the basal layer; multiple hairline-like forms showed excessive keratinization of the epidermis, papillary hyperplasia, and mild to moderate hypertrophy of the acanthosis. The dermis consists mainly of loose connective tissue, fibroblasts, collagen fibers, and dilated capillaries, which change similar to fibronectin.
Diagnosis
Diagnosis and diagnosis of pseudo acanthosis
Epidermal sputum: hyperkeratosis and acanthosis are more prominent, and there is obvious epidermal extension, epidermal atrophy is not common.
Seborrheic keratosis: often with pseudo-keratin cysts, keratosis.
Clinical features:
a. can occur at any age, about 50% of the onset of the disease after the middle age;
b. The cause is unknown and may be related to genetics, endocrine, drugs, tumors, etc.
c. Occurs in the skin folds, such as the neck, armpits, groin, nipple under the nipple;
d. gray-brown or black pigmentation, dry and rough surface, gradually thickened into small nipples, such as villi, can also progress into a scorpion or scorpion-like scorpion, velvet-like changes to its characteristic lesions;
e. may involve the mucosa, often with deck damage;
f. It can be divided into five types: malignant, true benign, pseudotype, syndrome and drug.
