Secondary Cutaneous CD30-Positive Large Cell Lymphoma
Introduction
Introduction to secondary skin CD30 positive large cell lymphoma A secondary cutaneous CD30 positive large cell lymphoma is a malignant tumor of the lymph node or lymphoid tissue. The clinical manifestations are painless and progressive lymphadenopathy. The disease can occur at any age, but the peak age of onset is 31 to 40 years old, and the peak of non-Hodgkin's lymphoma is slightly advanced. The ratio of male to female is: 2~3:1. Can occur in MF, lymphomatoid papulosis, and patients with extracutaneous involvement. basic knowledge The proportion of illness: the incidence rate is about 0.004%-0.008% Susceptible people: no special people Mode of infection: non-infectious Complications: lymphoma
Cause
Secondary skin CD30 positive large cell lymphoma etiology
Cause:
The cause is not clear, it can occur in MF, lymphoma-like papulosis, long-term diet structure, lifestyle and other factors cause excessive acidification of the body, the body's overall function rapidly declines, causing kidney deficiency, liver and kidney homology, kidney deficiency and liver deficiency, In turn, the body's metabolic cycle slows down, blood gas stagnate, and the body produces a large amount of acidic waste. At this time, some endogenous diseases will appear, and a large amount of acidic garbage will accumulate in the lymphoid cell system, and the tissue cells will become cancerous. And in patients affected by the skin.
Prevention
Secondary skin CD30 positive large cell lymphoma prevention
Choose healthy foods and beverages instead of high-fat, high-sugar and high-calorie foods, eat different types of vegetables, fruits, whole grains and legumes, reduce the consumption of red meat (beef, pork and lamb), and avoid processed meat. Class, limit the consumption of high-salt foods. For cancer prevention, try not to drink alcohol. If you drink alcohol, you should limit your daily alcohol consumption. Men should not be more than 2 cups per day, and women should not be more than 1 cup.
Complication
Secondary skin CD30 positive large cell lymphoma complications Complications lymphoma
1, gastrointestinal loss of appetite, abdominal pain, diarrhea, abdominal mass, intestinal obstruction and bleeding.
2, liver and gallbladder liver parenchymal can cause pain in the liver area.
3, the clinical manifestations of bones have local bone pain and secondary nerve compression symptoms.
4, skin non-specific damage commonly found in pruritus and pruritus. Itching is more common in Hodgkin's disease (85%).
Symptom
Secondary skin CD30 positive large cell lymphoma symptoms Common symptoms Nodular papules skin involvement
1. Non-MF-CD30 negative skin large T-cell lymphoma is a single or generalized plaque, nodule or tumor, no plaque phase can be distinguished from MF, poor prognosis, The 5-year survival rate is 15%. Some cases formerly known as demblee MF can be classified into this group of tumors. Extracutaneous involvement can occur almost simultaneously with skin involvement or with skin involvement.
2. Non-MF-CD30 negative cutaneous pleomorphic small or medium sized cell lymphoma (Non-MF-CD30 negative cutaneous pleomorphic small or medium sized cell lymphoma) is less than 30% of large pleomorphic cells The difference from MF is the clinical lack of patch and plaque damage, with one or several purplish red nodules or tumors. Extracutaneous involvement can occur almost simultaneously with skin involvement or with skin involvement.
Patients with lymphoma-like papulosis develop CD30+ lymphoma without other types of lymphoma, and the prognosis is good. The prognosis of MF patients with CD30 lymphoma is poor.
Examine
Secondary skin CD30 positive large cell lymphoma examination
The most important test is CD30 staining. CD30 is a Reed-Sternberg cell that is found in certain activated T and B cell markers, and can also be used to identify Hodgkin's disease. Monoclonal antibodies ki-1 and BerHz are used to identify CD30 positive if present. A large number of CD30-positive or more than 75% of the interstitial T cells are CD30-positive and may be considered as CD30+ cutaneous lymphoma, which is common in primary cutaneous T-cell CD30+ lymphoma.
1. Non-MF-CD30-negative skin large T-cell lymphoma histopathology: tumor cells are pleomorphic large or medium-sized, or immunoblastic, cells are brain-like, visible epidermal.
2. Histopathology of non-MF-CD30 negative skin pleomorphic small or moderate cell lymphoma: dense, diffuse or nodular dermal infiltration, tumor cells are small to medium-sized (>30%) T cells, And tend to infiltrate the subcutaneous tissue or epidermis.
Immunohistochemistry of non-MF-CD30 negative skin pleomorphic small or moderate cell lymphoma: tumor cells are T helper cell phenotype (CD4+), and in some cases self-presenting CD8+CD4-phenotype, tumor cells often lose all The T cell marker shows that TCR gene cloning rearrangement is difficult to identify histologically asexual reproduction because it is difficult to identify small to medium-sized cutaneous T-cell lymphoma and pseudo-T-cell lymphoma histologically. .
Diagnosis
Diagnosis and diagnosis of secondary skin CD30 positive large cell lymphoma
According to the clinical manifestations, the characteristics of skin lesions, the characteristics of tissue CD30 staining can be diagnosed.
Non-MF-CD30 negative cutaneous pleomorphic small or medium sized cell lymphoma (Non-MF-CD30 negative cutaneous pleomorphic small or medium sized cell lymphoma) is less than 30% of large pleomorphic cells. The difference in MF is the clinical lack of patch and plaque damage.
