Cornell rickettsial spotted fever
Introduction
Introduction to Connor's rickettular spotted fever Connolly rickettular spotted fever is typhoid fever, Mediterranean spotted fever (MSF), also known as North African typhus typhus, Kenyan bite fever, Indian rash typhus, Southern European spotted fever, pathogen is Kang R. conorii, another lesion is the North Asian rickettsial disease, the pathogen is Siberian rickettsia (R. siberica). The third type of rickettsial infection is the typhus typhus in Queensland. The pathogen is R. australis. The diseases caused by these pathogens include headache, fever, rash, and myalgia. basic knowledge The proportion of illness: 0.002% Susceptible people: more than children Mode of transmission: insect vector transmission complication:
Cause
Conorptive rickettsial fever
(1) Causes of the disease
The pathogen of this disease is Conorii rickettsia. The source of infection is a dog, a rodent, which is transmitted to humans through a bite.
(two) pathogenesis
The above three rickettsias are very similar to Rickettsia, and DNA hybridization proves that the latter has more than 90% homology with the rickettsia, and group-specific antigens. Although the same, but there are species-specific antige (species-specific antige) can be identified, they all invade endothelial cells, leading to cell death, causing vasculitis (see above), there is anxious at the bite.
Prevention
Connork rickettsial spot fever prevention
Preventive measures include mites, treatment of sick dogs and other rodents, attention to personal protection, external application of insect repellents, prevention of bites, and in-depth travel in Africa. People should pay attention to dressing, prevent biting, and travel to southern Europe. For example, in the spring and summer seasons, long-distance walking through suburban and rural areas, you should pay attention to search for cockroaches, and recover from these rickettsial infections, you can get strong immunity. In experimental animals, the rickettsia is more than most Rickettsia is relatively non-toxic, but animals recovered from infection with Rickettsia rickettsia also have a protective effect against the virulence of Rickettsia, which is provided by T lymphocytes, which also recognize plaques. The antigen of other species of rickettsia in the rash fever group.
Complication
Connork rickettsial rash heat complications Complication
There is no complication of this disease.
Symptom
Connork rickettsial rash heat symptoms common symptoms fatigue rash rash blush congestion hyperthermia muscle pain chills black spots local lymphadenopathy
The disease occurs mostly in children, the incubation period is 5 to 7 days, acute onset, manifested as chills, high fever, headache, joint pain, fatigue and other symptoms, a characteristic "black spot" appears at the bite, that is, the papule gradually Development of a central necrotizing black ulcer, surrounded by redness, local lymphadenopathy, and tenderness, the fourth day after the onset of the phenomenon of scattered reddish maculopapular rash, the palmar palpebral can also be involved, a small number of visible hemorrhagic damage.
The symptoms of this disease are mild, and the course of disease is about two weeks. With the decrease of body temperature, the rash gradually subsides. All three rickettsias are onset, and fever, headache, myalgia and conjunctival congestion are found. After 5 to 7 days, eschar is a characteristic symptom, which can confirm the diagnosis. It should be looked at in the scalp, armpit, groin and other sputum-like habitats. Because eschar is necrotic, the lymph nodes in this area can be drained. Swelling, eschar damage is like a cigarette burn, 2~5mm in diameter, black in the center, bulging edge, redness, tenderness, like RMSF, body rash on the 4th to 5th day, including palm and sole, vague Visible rash lesions are intradermal small bleeding points, with a course of about 2 weeks, with few deaths. Most cases of Weil-Felix reaction have agglutinating antibodies acting on OX19 antigen, which occurs about 2 to 3 weeks after the course of the disease.
Examine
Connork rickettsial spot fever check
The serological test is the first to test the antibodies to the rickettsial antibody by micro-immunofluorescence. If necessary, it can be a test.
Diagnosis
Connolly rickettsial spotted fever diagnosis
The disease is characterized by "black spots" at the bite of the insect, and a serum-specific complement binding test can be made in the early and recovery phase to make a diagnosis.
Attention should be distinguished from the jungle typhus, according to its different disease areas, clinical characteristics and special serological responses can be identified.
