actinoelastic fibrosis
Introduction
Introduction to photolinear elastic fiber disease Actinicelastosis, also known as solar elastic fiber syndrome (solarelastoticsyndrome), Favre-Racovchot syndrome, is a disease caused by long-term exposure to sun-induced skin degeneration, and different symptoms of the same nature include: neck Diamond skin, disseminated fibroids, nodular elastin, lemon skin, hand and foot collagen spots and ear elastic fibrous nodules. basic knowledge Sickness ratio: 0.001%-0.005% Susceptible people: no specific population Mode of infection: non-infectious Complications: skin allergies physical skin disease
Cause
Cause of photolinear elastic fiber disease
(1) Causes of the disease
In the long-term acceptance, short-wave ultraviolet rays cause degenerative skin degeneration, mainly due to elastic tissue degeneration, in which the content of hydroxyproline is low, and the elastic tissue is digested by enzyme to cause tissue degeneration to form an amorphous substance.
(two) pathogenesis
Elastic tissue degeneration, low hydroxyproline content, elastic tissue is digested by enzymes to undergo tissue denaturation, forming an amorphous substance.
Prevention
Photolinear elastic fiber disease prevention
This disease is caused directly by excessive light, so it should be avoided in the sun, and the exposed area can be coated with sunscreen. Especially for those who like to travel and long-term research, due to frequent exposure to the sun and ultraviolet radiation, it can increase the risk of the disease. For field workers and long-term travelers, pay attention to sun protection, such as Sunscreen and sunscreen can effectively reduce the risk of the disease.
Complication
Photolinear elastic fiber disease complications Complications skin allergies physical skin disease
The disease is mainly characterized by skin pigmentation and atrophy of the skin and its hair follicles. The elastic tissue is mainly degenerated, wherein the hydroxyproline content is low, and the elastic tissue is digested by the enzyme to cause tissue degeneration to form an amorphous substance. The integrity of the skin is easily destroyed, so it may cause skin bacterial infection or fungal infection due to scratching, usually secondary to low body constitution, or long-term use of immunosuppressive agents and fungal infections such as nail fungus, such as concurrent bacterial infection may have fever , skin swelling, ulceration and purulent secretion and other performance.
Symptom
Symptoms of light linear elastic fiber disease Common symptoms Skin rough skin Dry pimples Blackheads
It belongs to the different manifestations of photoelastic fibrosis and can be divided into six types.
1. The neck of the diamond (cutis rhomboidalis nuchae) also known as the peasants neck (peasants neck), the common symptoms are the neck of the skin is rough and thick, the sulcus is obvious, the vertical and horizontal lines intersect, forming a diamond-shaped skin, can also be extended to the amount, cheek, upper Chest and shoulder, or forearm extension, hand and foot can also be affected, no symptoms, chronic, farmers, sailors and athletes are prone to this disease, excessively exposed to the disease, usually older men, tissue pathology showing epidermal atrophy, basal cell layer Increased pigmentation, collagen fibrosis, basophilic degeneration, sweat glands, sebaceous glands and hair follicles are atrophied.
2. Nodular elastoidosis (also known as Favre-Rapuchot syndrome), mainly manifested as cheeks, periorbital, forehead, skin on both sides of the neck is pale yellow thickening, elastic reduction, wrinkles, orange peel The appearance can be complicated by most clusters of blackheads and follicular cysts, and the inflammatory reaction is obvious, which may be accompanied by senile deafness or other degenerative changes.
3. Diffuse elastoma of dubreuih often on the cheeks, the skin of the neck appears yellowish or orange plaques, the boundary is clear, can be single or multiple, easy to be confused with elastic fiber pseudo-yellow tumor, However, this disease is often caused by exposure to the sun, and can be distinguished without cardiovascular and fundus changes.
4. Cutrine skin milian Exposure to the sun area, the skin is yellow and thick and wrinkled.
5. Hand and foot collagen spots, also known as acrokerato-elastoidosis (acrokerato-elastoidosis) occurs in the palm of the hand and the back of the joint, from the tip of the thumb, around the fingertips to the fingertips of the skin is yellow or Fleshy hypertrophic papules or plaques, dry skin, may be associated with telangiectasia, and sometimes keratinized nodules lined up along the tendons in women's feet.
6. Elastotic nodules of ear are more common in elderly people with a history of long-term sun exposure, which may cause white or reddish unilateral or bilateral lumbar, translucent small nodules or papules, and aggregate with each other. It has an orange-like appearance, no symptoms, and is accompanied by other keratosis.
Examine
Examination of light linear elastic fiber disease
Histopathology: mild atrophy of the epidermis, a normal collagen fiber narrow band under the epidermis, broken coarse basophilic fibers in the upper 1/3 of the dermis or homogenized amorphous basophilic substances, positive staining of elastic fibers, Collagen fibers showed a few broken denatures, the distribution of melanin in the base layer was uneven, the increasing area and the decreasing area alternated, the eosin staining was lightly stained, the collagen bundle structure was unclear, horizontally arranged or amorphous, and contained a large amount of dense elastic fibers.
Diagnosis
Diagnosis and identification of photolinear elastic fiber disease
According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed.
It needs to be differentiated from elastic fiber pseudo-xanthoma, which mainly manifests multiple symptoms of skin, eye, cardiovascular and gastrointestinal tract. Histopathological elastic fiber and calcium deposition are different from this disease.
