neurofibromas of bone
Introduction
Introduction to skeletal nerve fibroma Neurofibroma is a benign tumor dominated by fibroblasts that grows in the nerve trunk and is a complex tumor of the skin, deep soft tissues, nerves and bones. basic knowledge The proportion of illness: 0.001% Susceptible people: good for adults Mode of infection: non-infectious Complications: scoliosis congenital sacral pseudoarthrosis congenital clavicle pseudoarthrosis
Cause
Cause of skeletal neurofibromatosis
(1) Causes of the disease
It is a benign tumor mainly composed of fibroblasts grown in the nerve trunk.
(two) pathogenesis
1. Generally seen: neurofibromas are not all connected with the large nerve trunk, but also from small unmyelinated fibers, loose and translucent thin envelope, no light or reactive area outside, invasive fibers Tumor disease can infiltrate surrounding normal tissues, and blunt dissection is difficult to achieve extracapsular capsular mass excision. For example, the tumor is connected to the main nerve trunk and often invades the nerve tissue. When the capsule is separated, the nerve fiber enters and penetrates the tumor. Unlike schwannomas, which do not invade nerve fibers, it is difficult to remove the nerves without damaging the nerves. Most of the large tumors are stage III lesions, and it is also common for the tumor to retreat into a cystic cavity containing yellow liquid.
2. Microscopic morphology: The main manifestation is that the loose spindle cells produce a fine fibrous eosin matrix, which is undulating and wavy, regular, with phagocytic cells, containing lipids and hemosiderin; also Verocay small Body, vascular proliferation, mature fat, mature fibrous nodules, etc., known as mixed neurofibroma.
Prevention
Osteofibroma prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Osteofibroma complications Complications scoliosis congenital sacral pseudoarthrosis congenital clavicle pseudoarthrosis
Can be complicated by scoliosis, congenital sacral pseudoarthrosis and congenital clavicular pseudoarthrosis, when the tumor compresses the common peroneal nerve can cause foot drop.
Symptom
Symptoms of skeletal neurofibroma common symptoms subcutaneous nodules grow slowly limb hypertrophy
Most of the patients are adults. The incidence of men and women is equal. It can be single or multiple. The adjacent bone can compress the bone, and the skeletal deformities such as scoliosis, congenital ankle joint and limb hypertrophy, multiple Neurofibromatosis has many skin nodules. Isolated deep neurofibroma grows slowly. It is found due to asymmetry or compression of nerves. Growth at the proximal end of the humerus can compress the common peroneal nerve and cause foot drop. Pain, but it is not uncommon to switch to fibrosarcoma.
Neurofibromas can have three benign stages, ie, delayed, active, and invasive; but can also be converted to sarcoma.
Examine
Examination of skeletal nerve fibroma
Neurofibroma in the bone can show long stripe morphology on X-ray films, but X-ray examination often has no positive findings.
Benign neurofibromatosis is an active stage II disease. There is no increase in absorption by radionuclide scanning. For example, there is a moderate increase in compression bone. A light angiographic response can be seen in angiography. In the late venous phase, there is no vascular area in the tumor. The position indicates that the tumor originated from the compression of the vascular nerve bundle, and CT did not help much.
Diagnosis
Diagnosis and diagnosis of skeletal neurofibromatosis
Diagnosis based on medical history, clinical manifestations, X-ray examination, radionuclide scanning and angiography, and ultimately rely on pathological diagnosis.
